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Ana Luisa Palhares de Miranda

• Camargo, GACG; Santos, MP; Silva, NLC; Miranda, ALP; Tributino, JLM. Levels of prostaglandin E2 (PGE2) in gingival crevicular fluid from smokers and non smokers with gegivitis and chronic periodontal disease. Journal of Dentistry and Oral Hygiene, 7, 54-59, 2015.

• Gabriela, ACGC; Fellows, EM; Dip, EC; Silva, NLC; Miranda, ALP; Tributino, JLM. Lidocaine subgingival irrigation modulate the levels of prostaglandin E2 in gingival crevicular fluid after periodontal therapy. Journal of Dentistry and Oral Hygiene, 7, 190-196, 2015.

Carlos Alberto Manssour Fraga

• Tabrizi, M; Baraldi, P; Baraldi, S; Prencipe, F; Preti, D; Saponaro, G; Romagnoli, R; Gessi, S; Merighi, S; Stefanelli, A; Fazzi, D; Borea, P; Maia, R; Romeiro, N; Fraga, CAM; Barreiro, EJ. Synthesis and biological evaluation of pyrazolo[3,4-b]pyridin-4-ones as a new class of topoisomerase II inhibitors. Medicinal Chemistry (Hilversum), 11, 342-353, 2015.

• Moura, VJG; Alencar, AKN; Calasans-Maia, JA; Silva, JS; Fraga, CAM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study. Urology (Ridgewood, N.J.), 85, 1214.e17-1214.e21, 2015.

• Pompeu, TET; Monte, FM ; Bosier, B; Fraga, CAM; Barreiro, EJ; Menegatti, R; Hermans, E; Noël, FG. Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 62, 1-6, 2015.

• Sato, JAP; Costa, FN; Rocha, MD; Barreiro, EJ; Fraga, CAM; Punzo, F; Ferreira, FF. Structural characterization of LASSBio-1289: a new vasoactive N-methyl-N-acylhydrazone derivative. CrystEngComm (Cambridge. Online), 17, 165-173, 2015.

• Monteiro, CE; Nascimento-Júnior, NM; Trachez, MM ; Tesch, R; Mendes, TCF; Fraga, CAM; Santanna, CM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Prevention and reversal of morphine-induced tolerance by novel muscarinic receptor agonist in rats with neuropathic pain. Journal of Neurology and Neurophysiology, 6, 1000282, 2015.

• Cortopassi, WA; Ramalho, TC; Fraga, CAM; Mangas, I ; Kuca, K; Franca, TCC. Bubonic plague: historical aspects and therapy. Military Medical Science Letters, 84, 67-75, 2015.

• Marques, EB; Motta, NAV; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Brito, FCF; Scaramello, CBV. In vivo effect of LASSBio-785, a lipid-lowering and anti-inflammatory agent, on cardiac Ca2^+-ATPases from hypercholesterolemic rats. International Journal of Cardiology (Print), 201, 282-284, 2015.

Cláudia Lucia Martins da Silva

• Nascimento-Viana, JB; Carvalho, AR; Nasciutti, LE; Alcantara-Hernandez, R; Chagas-Silva, F; Souza, PAVR; Romeiro, LA; Garcia-Sainz, JA; Noël, FG; Silva, CLM. New multi-target antagonists of alpha1A-, alpha1D-adrenoceptors and 5-HT1A receptors reduce human hyperplastic prostate cell growth and the increase of intraurethral pressure. The Journal of Pharmacology and Experimental Therapeutics (Online), 1, 1, 2015.

Didier Jean Jacques Salmon

• Hamedi, A; Botelho, L; Britto, C; Fragoso, SP; Umaki, ACS; Goldenberg, S; Bottu, G; Salmon, DJJ. In vitro metacyclogenesis of Trypanosoma cruzi induced by starvation correlates with a transient adenylyl cyclase stimulation as well as with a constitutive upregulation of adenylyl cyclase expression. Molecular and Biochemical Parasitology (Print), 200, 9-18, 2015.

• Dias, FA; Guerra, B; Vieira, LR; Perdomo, HD; Gandara, ACP; Amaral, RJV; Vollú, RE; Gomes, SAO; Lara, FA; Sorgine, MHF ; Medei, E ; Oliveira, PL; Salmon, DJJ. Monitoring of the parasite load in the digestive tract of Rhodnius prolixus by combined GPCr analysis and imaging techniques provides new insights into the Trypanosome life cycle. PLoS Neglected Tropical Diseases (Online), 9, e0004186, 2015.

• Horáková, E; Changmai, P; Paris, Z; Salmon, DJJ; Luke, J. Simultaneous depletion of Atm and Mdl rebalances cytosolic Fe-S cluster assembly but not heme import into the mitochondrion of Trypanosoma brucei. The FEBS Journal (Print), 282, 2015.

• Vionette-Amaral, RD; Lowenberger, RJ; Rivera-Pomar, C; Monteiro, R; Minx, FA; Spieth, P; Carvalho, J; Panzera, AB; Lawson, F; Torres, D; Ribeiro, AQ; Sorgine, JMC; Waterhouse, MHF; Montague, RM; Abad-Franch, MJ; Alves-Bezerra, F; Amaral, M; Araujo, LR; Araujo, HM; Aravind, RN; Atella, L; Azambuja, GC; Berni, P; Bittencourt-Cunha, M. et al. Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection. Proceedings of the National Academy of Sciences of the United States of America, 112, 14936-14941, 2015.

• Vieira, LR; Polomé, A; Mesquita, RD; Salmon, DJJ; Braz, GRC; Bousbata, S. Protein 2DE reference map of the anterior midgut of the blood-sucking bug. Proteomics (Weinheim. Print), 15, 3901-3904, 2015.

Eliezer Jesus de Lacerda Barreiro

• Oliveira, VR; Avila, MB; Carvalho, GMC; Azevedo, SMFO; Lima, LM; Barreiro, EJ; Carvalho, AR; Zin, WA. Investigating the therapeutic effects of LASSBio-596 in an in vivo model of cylindrospermopsin-induced lung injury. Toxicon (Oxford), 94, 29-35, 2015.

• Silva, TF; Bispo Júnior, W; Alexandre-Moreira, MS; Costa, FN; Monteiro, C; Ferreira, FF; Barroso, RCR; Noël, FG; Sudo, RT; Zapata-Sudo, G; Lima, LM; Barreiro, EJ. Novel orally active analgesic and anti-inflammatory cyclohexyl-n-acylhydrazone derivatives. Molecules (Basel. Online), 20, 3067-3088, 2015.

• Moura, VJG; Alencar, AKN; Calasans-Maia, JA; Silva, JS; Fraga, CAM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study. Urology (Ridgewood, N.J.), 85, 1214.e17-1214.e21, 2015.

• Pompeu, TET; Monte, FM ; Bosier, B; Fraga, CAM; Barreiro, EJ; Menegatti, R; Hermans, E; Noël, FG. Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 62, 1-6, 2015.

• Alves, MA; Queiroz, AC; Alexandre-Moreira, MS; Varela, J; Cerecetto, H; González, M; Doriguetto, AC; Landre, IM; Barreiro, EJ; Lima, LM. Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives. European Journal of Medicinal Chemistry, 100, 24-33, 2015.

• Costa, FN; Silva, TF; Miguez, E; Barroso, RC; Braz, D; Barreiro, EJ; Lima, LM; Punzo, F; Ferreira, FF. Structural features evolution - from fluids to solid phase - and crystal morphology study of LASSBio 1601: a cyclohexyl-N-acylhydrazone derivative. RSC Advances: An International Journal to Further the Chemical Sciences, 5, 39889-39898, 2015.

• Thota, S; Vallala, S; Yerra, R; Barreiro, EJ. Design, synthesis, characterization, cytotoxic and structure activity relationships of novel Ru(II) complexes. Chinese Chemical Letters, 26, 721-726, 2015.

• Monteiro, CE; Nascimento-Júnior, NM; Trachez, MM ; Tesch, R; Mendes, TCF; Fraga, CAM; Santanna, CM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Prevention and reversal of morphine-induced tolerance by novel muscarinic receptor agonist in rats with neuropathic pain. Journal of Neurology and Neurophysiology, 6, 1000282, 2015.

• Tabrizi, M; Baraldi, P; Baraldi, S; Prencipe, F; Preti, D; Saponaro, G; Romagnoli, R; Gessi,; Merighi, S; Stefanelli, A; Fazzi, D; Borea, P; Maia, R; Romeiro, N; Fraga, CAM; Barreiro, EJ. Synthesis and biological evaluation of pyrazolo[3,4-b]pyridin-4-ones as a new class of topoisomerase II inhibitors. Medicinal Chemistry (Hilversum), 11, 342-353, 2015.

• Marques, EB; Motta, NAV; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Brito, FCF; Scaramello, CBV. In vivo effect of LASSBio-785, a lipid-lowering and anti-inflammatory agent, on cardiac Ca2^+-ATPases from hypercholesterolemic rats. International Journal of Cardiology (Print), 201, 282-284, 2015.

• Padilha, GA; Henriques, I; Lopes-Pacheco, M; Abreu, SC; Oliveira, MV; Morales, MM; Lima, LM; Barreiro, EJ; Silva, PL; Xisto, DG; Rocco, PRM. Therapeutic effects of LASSBio-596 in an elastase-induced mouse model of emphysema. Frontiers in Physiology, 6, 01-10, 2015.

• Moraes, BKS; Bajerski, L; Parisotto, A; Silva, CER; Amaral, MA; Barreiro, EJ; Freddo, RJ; Dalla Costa, T; Lima, LM; Haas, SE. Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4 (trifluoromethyl) benzylidene) - 5 - (2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment. BMC. Biomedical Chromatography, 6, 2015.

Fabio de Sousa Menezes Boylan

• Pinheiro, MMG; Miltojevic, AB; Radulovic, NS; Abdul-Wahab, IR; Boylan, F; Fernandes, PD. Anti-inflammatory activity of Choisya ternata Kunth essential oil, ternanthranin, and its two synthetic analogs (methyl and propyl n-methylanthranilates). Plos One, 10, e0121063, 2015.

• Guilhon, CC; Wahab, IRA; Boylan, F; Fernandes, PD. Central Antinociceptive and mechanism of action of Pereskia bleo kunth leaves crude extract, fractions, and isolated compounds. Evidence-Based Complementary and Alternative Medicine (Print), 2015, 1-12, 2015.

Floriano Paes Silva Junior

• Gasparotto, J; Senger, MR; Kunzler, A; Degrossoli, A; Simone, SG; Bortolin, RC; Somensi, N; Girardi, CS; Souza, CSF; Calabrese, KS; Dal-Pizzol, F; Moreira, JCF; Silva-Jr, FP; Gelain, DP. Increased tau phosphorylation and receptor for advanced glycation endproducts (RAGE) in the brain of mice infected with Leishmania amazonensis. Brain, Behavior, and Immunity, 43, 37-45, 2015.

François Germain Noel

• Muller, LG; Salles, L; Lins, HA; Feijo, PRO; Cassel, E; Vargas, R; Poser, GLV; Noël, FG; Quintas, LEM; Rates, SMK. Effects of diene valepotriates from Valeriana glechomifolia on Na+/K+-ATPase activity in the cortex and hippocampus of mice. Planta Medica, 81, 200-207, 2015.

• Paula, NC; Cordeiro, KCFA; Souza, PLM; Nogueira, DF; Sousa, DBS; Costa, MB; Noël, FG; Oliveira, V. Biosynthesis of human diazepam and clonazepam metabolites. Bioorganic & Medicinal Chemistry Letters (Print), 25, 1026-1029, 2015.

• Silva, TF; Bispo Júnior, W; Alexandre-Moreira, MS; Costa, FN; Monteiro, C; Ferreira, FF; Barroso, RCR; Noël, FG; Sudo, RT; Zapata-Sudo, G; Lima, LM; Barreiro, EJ. Novel orally active analgesic and anti-inflammatory cyclohexyl-n-acylhydrazone derivatives. Molecules (Basel. Online), 20, 3067-3088, 2015.

• Alves, SLG; Paixão, N; Ferreira, LGR; Santos, FRS; Neves, LDR; Oliveira, GC; Cortes, VF; Salomé, KS; Barison, A; Santos, FV; Cenzi, G; Varotti, FP; Oliveira, SMF; Taranto, AG; Comar, M; Silva, LM; Noël, FG; Quintas, LEM; Barbosa, LA; Villar, JAFP. γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect. Bioorganic & Medicinal Chemistry (Print), 23, 4397-4404, 2015.

• Cordova, WP; Leitão, SG; Cunha-Filho G; Bosch, RA; Alonso, IP; Gervou, R; Quintas, LEM; Noël, FG. Bufadienolides from parotoid gland secretions of Cuban toad Peltophryne fustiger (Bufonidae): inhibition of human kidney Na+/K+-ATPase activity. Toxicon (Oxford), 110, 27-34, 2015.

• Pompeu, TET; Monte, FM ; Bosier, B; Fraga, CAM; Barreiro, EJ; Menegatti, R; Hermans, E; Noël, FG. Partial agonism and fast dissociation of LASSBio-579 at dopamine D2 receptor. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 62, 1-6, 2015.

Gisele Zapata Sudo

• Silva, TF; Bispo Júnior, W; Alexandre-Moreira, MS; Costa, FN; Monteiro, C; Ferreira, FF; Barroso, RCR; Noël, FG; Sudo, RT; Zapata-Sudo, G; Lima, LM; Barreiro, EJ. Novel orally active analgesic and anti-inflammatory cyclohexyl-n-acylhydrazone derivatives. Molecules (Basel. Online), 20, 3067-3088, 2015.

• Moura, VJG; Alencar, AKN; Calasans-Maia, JA; Silva, JS; Fraga, CAM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study. Urology (Ridgewood, N.J.), 85, 1214.e17-1214.e21, 2015.

• Marques, A; Pereira, SL; Cavalcante, C; Sudo, RT; Sudo, SZ; Kaplan, MAC; Zapata-Sudo, G. Hypoglycemic effect of the methanol flower extract of Piper claussenianum and the major constituent 2,6-dihydroxy-4-methoxychalcone in streptozotocin diabetic rats. Indian Journal of Pharmaceutical Science, 77, 222, 2015.

• Andrade, BM; Baldanza, MR; Ribeiro, KC; Porto, A; Peçanha, R; Fortes, FSA; Zapata-Sudo, G; Campos-de-Carvalho, AC; Goldenberg, RCS; Werneck-de-Castro, JP. Bone marrow mesenchymal cells improve muscle function in a skeletal muscle re-injury model. Plos One, 10, e0127561, 2015.

• Monteiro, CE; Nascimento-Júnior, NM; Trachez, MM ; Tesch, R; Mendes, TCF; Fraga, CAM; Santanna, CM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Prevention and reversal of morphine-induced tolerance by novel muscarinic receptor agonist in rats with neuropathic pain. Journal of Neurology and Neurophysiology, 6, 1000282, 2015.

• Silva, JS; Pereira, SL; Maia, RC; Landgraf, SS; Caruso-Neves, C; Kümmerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life Sciences (1973), 94, 30-36, 2014.

Josiane Sabbadini Neves

• Muniz, VS; Reis, RB; Benjamim, CF; Mata-Santos, HA; Pyrrho, AS; Strauch, MA; Melo, PA; Vicentino, ARR; Silva-Paiva, J; Bandeira-Melo, C; Weller, PF; Figueiredo, RT; Neves, JS. Purinergic P2Y12 receptor activation in eosinophils and the schistosomal host response. Plos One, 10, e0139805, 2015.

• Baptista-dos-Reis, R; Muniz, V; Neves, JS. Multifaceted roles of cysteinyl leukotrienes in eliciting eosinophil granule protein secretion. Biomed Research International, 2015, 1-7, 2015.

Lidia Moreira Lima

• Oliveira, VR; Avila, MB; Carvalho, GMC; Azevedo, SMFO; Lima, LM; Barreiro, EJ; Carvalho, AR; Zin, WA. Investigating the therapeutic effects of LASSBio-596 in an in vivo model of cylindrospermopsin-induced lung injury. Toxicon (Oxford), 94, 29-35, 2015.

• Silva, TF; Bispo Júnior, W; Alexandre-Moreira, MS; Costa, FN; Monteiro, C; Ferreira, FF; Barroso, RCR; Noël, FG; Sudo, RT; Zapata-Sudo, G; Lima, LM; Barreiro, EJ. Novel orally active analgesic and anti-inflammatory cyclohexyl-n-acylhydrazone derivatives. Molecules (Basel. Online), 20, 3067-3088, 2015.

• Costa, FN; Silva, TF; Miguez, E; Barroso, RC; Braz, D; Barreiro, EJ; Lima, LM; Punzo, F; Ferreira, FF. Structural features evolution - from fluids to solid phase - and crystal morphology study of LASSBio 1601: a cyclohexyl-N-acylhydrazone derivative. RSC Advances: An International Journal to Further the Chemical Sciences, 5, 39889-39898, 2015.

• Lima, LM. Safrole and the versatility of a natural biophore. Revista Virtual de Química, 7, 495-538, 2015.

• Alves, MA; Queiroz, AC; Alexandre-Moreira, MS; Varela, J; Cerecetto, H; González, M; Doriguetto, AC; Landre, IM; Barreiro, EJ; Lima, LM. Design, synthesis and in vitro trypanocidal and leishmanicidal activities of novel semicarbazone derivatives. European Journal of Medicinal Chemistry, 100, 24-33, 2015.

• Padilha, GA; Henriques, I; Lopes-Pacheco, M; Abreu, SC; Oliveira, MV; Morales, MM; Lima, LM; Barreiro, EJ; Silva, PL; Xisto, DG; Rocco, PRM. Therapeutic effects of LASSBio-596 in an elastase-induced mouse model of emphysema. Frontiers in Physiology, 6, 01-10, 2015.

• Moraes, BKS; Bajerski, L; Parisotto, A; Silva, CER; Amaral, MA; Barreiro, EJ; Freddo, RJ; Dalla Costa, T; Lima, LM; Haas, SE. Simple HPLC-UV for the quantification of a new leishmanicidal candidate (E)-1-4 (trifluoromethyl) benzylidene) - 5 - (2-4-dichlorozoyl) carbonylhydrazine (LASSBio-1736) in rat plasma for pharmacokinetics assessment. BMC. Biomedical Chromatography, 6, 2015.

Lucienne da Silva Lara Morcillo

• Gonzalez, AA; Liu, L; Lara, LS; Bourgeois, CRT; Ibaceta-Gonzalez, C; Salinas-Parra, N; Gogulamudi, VR; Seth, DM; Prieto, MC. PKCα-dependent augmentation of cAMP and CREB phosphorylation mediates the angiotensin II stimulation of renin in the collecting duct. American Journal of Physiology. Renal Physiology, 309, 880-888, 2015.

• Muzi-Filho, H; Souza, AM; Bezerra, CGP; Boldrini LC; Takya, CM ; Oliveira, FL; Nesi, RT; Valenca, SS; Silva, AMS; Sudo, GZ; Sudo, RT; Einicker-Lamas, M; Vieyra, A; Lara, LS; Cunha, VMN. Rats undernourished in utero have altered Ca ²⁺ signaling and reduced fertility in adulthood. Physiological Reports, v. 3, p. e12587, 2015.

Luis Eduardo Menezes Quintas

• Muller, L; Salles, L; Lins, HA; Feijo, PR; Cassal, E; Vargas, R; Von Poser, G; Noël, FG; Quintas, LEM; Rates, SMK. Effects of diene valepotriates from Valeriana glechomifolia on Na+/K+-ATPase activity in the cortex and hippocampus of mice. Planta Medica, 81, 200-207, 2015.

• Neustadt, T; Possidonio, ACB; Soares, CP; Ayres, RO; Costa, ML; Quintas, LEM; Mermelstein, C. The Role of Na+/K+-ATPase during chick skeletal myogenesis. Plos One, 10, p. e0120940, 2015.

• Ayres, RO; Feijo, PR; Cintra, AC; Tomaz, MA; Melo, PA; Cunha, VMN; Quintas, LEM. Different effects of myotoxins bothropstoxin-I and II from Bothrops snake venom on cation transport ATPases from murine fast twitch skeletal muscle. Toxicon (Oxfor), 103, 80-84, 2015.

• Alves, SLG; Paixão, N; Ferreira, LGR; Santos, FRS; Neves, LDR; Oliveira, GC; Cortes, VF; Salomé, KS; Barison, A; Santos, FV; Cenzi, G; Varotti, FP; Oliveira, SMF; Taranto, AG; Comar, M; Silva, LM; Noël, FG; Quintas, LEM; Barbosa, LA; Villar, JAFP. γ-Benzylidene digoxin derivatives synthesis and molecular modeling: Evaluation of anticancer and the Na,K-ATPase activity effect. Bioorganic & Medicinal Chemistry (Print), 23, 4397-4404, 2015.

Luzineide Wanderley Tinoco

• Malafaia, CRA; Silva, BP; Tinoco, LW; Parente, JP. Structural characterization and gastroprotective property of a novel glucofructan from Allium ampeloprasum var. porrum. Carbohydrate Research (Chicago, Ill.. Print), 402, 44-49, 2015.

• Costa, IFB; Calixto, SD; Araujo, MH; Konno, TUP; Tinoco, LW; Guimarães, DO; Lasunskaia, EB; Leal, IRC; Muzitano, MF. Antimycobacterial and nitric oxide production inhibitory activities of Ocotea notata from brazilian restinga. The Scientific World Journal, 2015, 1-9, 2015.

• Nascimento, RRG; Pimenta, ATA; Lima Neto, P; Cândido Júnior, JR; Costa-Lotufo, LV; Ferreira, EG; Tinoco, LW; Braz-Filho, R; Silveira, ER; Lima, MAS. New Alkaloids from Margaritopsis carrascoana (Rubiaceae). Journal of the Brazilian Chemical Society (Impresso), 2015.

• Marques, AM; Paiva, RA; Sudo, RT; Tinoco, LW; Kaplan, MAC; Sudo, GT. Hypoglycemic Effect of the methanol flower extract of Piper claussenianum and the major constituent 2′,6′-dihydroxy-4′-methoxychalcone in streptozotocin diabetic rats. Indian Journal of Pharmaceutical Science, 77, 237-243, 2015.

• Fredi, ARO; Tinoco, LW. Sphingolipids: bioactive metabolites and models for drug design. Revista Virtual de Química, 7, 1384-1401, 2015.

Marco Aurélio Martins

• Barreto, E; Serra, MF; Santos, RV; Santos, CEA; Hickmann, J; Cotias, AC; Pão, CRR; Trindade, SG; Schimidt, V; Giacomelli, C; Carvalho, VF; Silva, PMR; Cordeiro, RSB; Martins, MA. Local administration of gold nanoparticles prevents pivotal pathological changes in murine models of atopic asthma. Journal of Biomedical Nanotechnology, 11, 1038-1050, 2015.

• Olsen, PC; Kitoko, JZ; Ferreira, TP; De-Azevedo, CT; Arantes, AC; Martins, MA. Glucocorticoids decrease Treg cell numbers in lungs of allergic mice. European Journal of Pharmacology, 747, 52-58, 2015.

• Reis, AC; Ferreira, TPT; Coutinho, DS; Arantes, ACS; Martins, MA; Teixeira, MM; Pinho, V. Induction of eosinophil apoptosis by hydrogen peroxide promotes the resolution of allergic inflammation. Cell Death & Disease, 6, e1632, 2015.

• Trentin, PG; Ferreira, TPT; Arantes, ACS; Ciambarella, BT; Cordeiro, RSB; Flower, RJ; Perretti, M; Martins, MA; Silva, PMR. Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice. British Journal of Pharmacology, 172, 3058-3071, 2015.

• Insuela, DBR; Daleprane, JB; Coelho, LP; Silva, AR; Silva, PMR; Martins, MA; Carvalho, VF. Glucagon induces airway smooth muscle relaxation by nitric oxide and prostaglandin E2. Journal of Endocrinology, 225, 205-217, 2015.

Newton Gonçalves de Castro

• Acquarone, M; Melo, TM; Meireles, F; Brito-Moreira, J; Oliveira, G; Ferreira, ST; Castro, NG; Tovar-Moll, F; Houzel, JC; Rehen, SK. Mitomycin-treated undifferentiated embryonic stem cells as a safe and effective therapeutic strategy in a mouse model of Parkinson’s disease. Frontiers in Cellular Neuroscience, 9, 1-11, 2015.

• Potas, JR; Castro, NG; Maddess, T; Souza, MN. Waveform similarity analysis: a simple template comparing approach for detecting and quantifying noisy evoked compound action potentials. Plos One, 10, e0136992, 2015.

• Petronilho, EC; Rennó, MN; Castro, NG; Silva, FMR; Pinto, AC; Figueroa-Villar, JD. Design, synthesis, and evaluation of guanylhydrazones as potential inhibitors or reactivators of acetylcholinesterase. Journal of Enzyme Inhibition and Medicinal Chemistry (Online), 30, 1-10, 2015.

• Lemes, LFN; Ramos, GA; Oliveira, AS; Silva, FMR; Couto, GC; Boni, MS; Guimarães, MJR; Souza, INO; Bartolini, M; Andrisano, V; Nogueira, PCN; Silveira, ER; Brand, GD; Soukup, O; Romeiro, NC; Castro, NG; Bolognesi, ML; Romeiro, LAS. Cardanol-derived AChE inhibitors: towards the development of dual binding derivatives for Alzheimer’s disease. European Journal of Medicinal Chemistry, 109, 1, 2015.

Nubia Boechat

• Magalhães JL; Quoniam, L; Boechat, N. La propriété industrielle dans le cancer et le droit à la vie: cas de l'intelligence économique au Brésil associé à la tuberculose. Revue Internationale d'Intelligence Économique, 7, 47-61, 2015.

• Costa, CCP; Boechat, N; Silva, FC; Rosario, SL; Bezerra, TC; Bastos, MM. The Efavirenz: structure-activity relationship and synthesis methods. Revista Virtual de Química, 7, 1347-1370, 2015.

• Carvalho, AS; Duarte, SL; Costa, JC; Boechat, N. A new process for obtaining meglumine antimoniate aiming at the production of generic drug. Revista Virtual de Química, 7, 684-696, 2015.

• Boechat, N; Carvalho, AS; Salomão, K; Castro, SL; Araujo-Lima, CF; Mello, FV; Felzenszwalb, I; Aiub, CAF; Conde, TR; Zamith, HPS; Skupin, R; Haufe, G. Studies of genotoxicity and mutagenicity of nitroimidazoles: demystifying this critical relationship with the nitro group. Memórias do Instituto Oswaldo Cruz (Online), 110, 00-00, 2015.

• Pinheiro, LCS; Boechat, N; Ferreira, MLG; Júnior, CCS; Jesus, AML; Leite, MMM; Souza, NB; Krettli, AU. Anti-Plasmodium falciparum activity of quinoline-sulfonamide hybrids. Bioorganic & Medicinal Chemistry (Print), 23, 5979-5984, 2015.

• Boechat, N; Bastos, MM. Selective fluorination methods of organic molecules. Química Nova (Impresso), 38, 1323-1338, 2015.

• Branco, FSC; Silva, BV; Rio, GF; Santana, MJ; Queiroz Junior, LHK; Pinto, AC; Liao, LM; Boechat, N. Ressonância magnética nuclear de substâncias organofluoradas: um desafio no ensino de espectroscopia. Química Nova (Impresso), 38, 1237-1246, 2015.

• Leite, DI; Azevedo, LD; Farias, JV; Figueiredo, YV; Martins, WA; Bianco, MCAD; Bernardino, AMR; Bastos, MM; Boechat, N. Tenofovir: relação estrutura-atividade e métodos de síntese. Revista Virtual de Química, 7, 2347-2376, 2015.

• Silva, ER; Boechat, N; Pinheiro, LCS; Bastos, MM; Costa, CCP; Bartholomeu, JC; Costa, TH. Novel selective inhibitor of Leishmania (Leishmania) amazonensis arginase. Chemical Biology & Drug Design (Print), 86, p. n/a-n/a, 2015.

Patricia Dias Fernandes

• Pinheiro, MMG; Miltojevic, AB; Radulovic, NS; Abdul-Wahab, IR; Boylan, F; Fernandes, PD. Anti-inflammatory activity of Choisya ternata Kunth essential oil, ternanthranin, and its two synthetic analogs (methyl and propyl n-methylanthranilates). Plos One, 10, e0121063, 2015.

• Vieira, AA; Marinho, BG; Souza, LG; Fernandes, PD; Figueroa-Villar, JD. Design, synthesis and in vivo evaluation of sodium 2-benzyl-chloromalonates as new central nervous system depressants. MedChemComm, 1427-1437, 2015.

• Giorno, TBS; Ballard, YLL; Cordeiro, MS; Silva, BV; Pinto, AC; Fernandes, PD. Central and peripheral antinociceptive activity of 3-(2-oxopropyl)-3-hydroxy-2-oxindoles. Pharmacology, Biochemistry and Behavior, 135, 13-19, 2015.

• Guilhon, CC; Wahab, IRA; Boylan, F; Fernandes, PD. Central Antinociceptive and mechanism of action of Pereskia bleo kunth leaves crude extract, fractions, and isolated compounds. Evidence-Based Complementary and Alternative Medicine (Print), 2015, 1-12, 2015.

• Guedes, IA; Freitas, RHCN; Cordeiro, NM; Nascimento, TS; Valerio, TS; Fernandes, PD; Dardenne, LE; Fraga, CAM. LASSBio-1829 hydrochloride: development of a new orally active n -acylhydrazone IKK2 inhibitor with anti-inflammatory properties. Chemmedchem (Print), 11, 234-244, 2015.

• Campos, VR; Cunha, AC; Silva, WA; Ferreira, VF; Sousa, CS; Fernandes, PD; Moreira, VN; Rocha, DR; Dias, FFR; Montenegro, RC; Souza, MCBV; Boechat, FCS; Franco, CFJ; Resende, JALC. Synthesis of a new class of naphthoquinone glycoconjugates and evaluation of their potential as antitumoral agents. RSC Advances: an international journal to further the chemical sciences, 5, 96222-96229, 2015.

• Silva, JH; Borges, VRA; Pereira, LCB; Ferrari, R; Mattos, RM; Barros, EGO; Palmero, CY; Fernandes, PD; Carvalho, PR; Sousa, VP; Cabral, LM; Nasciutti, LE. The oil-resin of the tropical rainforest tree Copaifera langsdorffii reduces cell viability, changes cell morphology and induces cell death in human endometriotic stromal cultures. Journal of Pharmacy and Pharmacology, 67, 1744-1755, 2015.

Paulo de Assis Melo

• Monteiro-Machado, M; Tomaz, MA; Fonseca, RJC; Strauch, MA; Cons, BL; Borges, PA; Patrão-Neto, FC; Tavares-Henriques, MS; Teixeira-Cruz, JM; Calil-Elias, S; Cintra, ACO; Martinez, AMB; Mourão, PAS; Melo, PA. Occurrence of sulfated fucose branches in fucosylated chondroitin sulfate are essential for the polysaccharide effect preventing muscle damage induced by toxins and crude venom from Bothrops jararacussu snake. Toxicon (Oxford), 98, 20-33, 2015.

• Ribeiro, MF; Oliveira, FL; Monteiro-Machado, M; Cardoso, PF; Guilarducci-Ferraz, VVC; Melo, PA; Souza, CMV; Calil-Elias, S. Pattern of inflammatory response to Loxosceles intermedia venom in distinct mouse strains: A key element to understand skin lesions and dermonecrosis by poisoning. Toxicon (Oxford), 96, 10-23, 2015.

• Guimarães, MA; Ramundo, MS; Américo, MA; Mattos, MC; Souza, RR; Ramos-Júnior, ES; Coelho, LR; Morrot, A; Melo, PA; Fracalanzza, SEL; Ferreira, FA; Figueiredo, AMS. A comparison of virulence patterns and in vivo fitness between hospital- and community-acquired methicillin-resistant Staphylococcus aureus related to the USA400 clone. European Journal of Clinical Microbiology & Infectious Diseases (Print), 34, 497-509, 2015.

• Ayres, R; Feijó, PRO; Cintra, ACO; Tomaz, MA; Melo, PA; Cunha, VMN; Quintas, LEM. Different effects of myotoxins bothropstoxin-I and II from Bothrops snake venom on cation transport ATPases from murine fast twitch skeletal muscle. Toxicon (Oxford), 103, 80-84, 2015.

• Muniz, VS; Reis, RB; Benjamim, CF; Mata-Santos, HA; Pyrrho, AS; Strauch, MA; Melo, PA; Vicentino, ARR; Silva-Paiva, J; Bandeira-Melo, C; Weller, PF; Figueiredo, RT; Neves, JS. Purinergic P2Y12 receptor activation in eosinophils and the schistosomal host response. Plos One, 10, e0139805, 2015.

Paulo Roberto Ribeiro Costa

• Manvar, D; Fernandes, TA; Domingos, JLO; Baljinnyam, E; Basu, A; Junior, EFT; Costa, PRR; Kaushik-Basu, N. Synthesis and biological evaluation of α-aryl-α-tetralone derivatives as hepatitis C virus inhibitors. European Journal of Medicinal Chemistry, 93, 51-54, 2015.

• Faria, F; Leal, MB; Bernardo, P; Costa, PRR; Maia, R. NFκB Pathway and microRNA-9 and -21 are involved in sensitivity to the pterocarpanquinone LQB-118 in different CML cell lines. Anti-Cancer Agents in Medicinal Chemistry, 15, 345-352, 2015.

• Buarque, C; Domingos, J; Netto, C; Costa, PRR. Palladium-catalyzed oxyarylation, azaarylation and α-arylation reactions in the synthesis of bioactive isoflavonoid analogues. Current Organic Synthesis, 12, 772-794, 2015.

• Silva, KL; Souza, PS; Costa, PRR; Maia, RC. Abstract A51: Antineoplastic activity of novel synthetic compound pterocarpanquinone LQB-118 in lung cancer cells. Clinical Cancer Research (Print), 21, A51-A51, 2015.

• Reis, FRS; Mororó, JS; Silva, KL; Buarque, CD; Costa, PRR; Maia, RC. Abstract A49: Efficiency of 11a-N-tosyl-5-deoxi-pterocarpan (LQB-223) in a panel of myeloid leukemia cell lines with different chemoresistance backgrounds. Clinical Cancer Research (Print), 21, A49-A49, 2015.

• Costa, DSS; Martino, T; Magalhães, FC; Justo, G; Coelho, MGP; Barcellos, JCF; Moura, VB; Costa, PRR; Sabino, KCC; Dias, AG. Synthesis of N-methylarylnitrones derived from alkyloxybenzaldehydes and antineoplastic effect on human cancer cell lines. Bioorganic & Medicinal Chemistry (Print), 23, 2053-2061, 2015.

• Costa, PRR; Sansano, JM; Cossío, U; Barcellos, JCF; Dias, AG; Nájera, C; Arrieta, A; Cózar, A; Cossío, FP. Synthesis of chromen[4,3- b ]pyrrolidines by intramolecular 1,3-dipolar cycloadditions of azomethine ylides: an experimental and computational assessment of the origin of stereocontrol. European Journal of Organic Chemistry (Print), 2015, 4689-4698, 2015.

• Buarque, C; Costa, PRR; Dias, A; Barcellos, J; Borges, B; Mendes, J; Ceron, M. Synthesis of 11a-N-arylsulfonyl-5-carbapterocarpans (tetrahydro-5H-benzo[a]carbazoles) by azaarylation of dihydronaphthalenes with o-iodo-n-(arylsulfonyl)anilines in poly(ethylene glycol). Synthesis (Stuttgart), 47, 3013-3019, 2015.

• Costa, PRR; Moraes, P; Gaspar, F; Borges, R; Netto, C; Leão, R; Nájera, C. Ligand-free palladium-catalyzed oxyarylation of dihydronaphthal¬enes and chromenequinone with o-iodophenols and 3-iodolawsone in PEG-400: An efficient synthesis of 5-carbapterocarpans and pterocarpanquinones. Synthesis (Stuttgart), 47, 3505-3512, 2015.

• Silva, LLR; Portes, JA; Araújo, MH; Silva, JLS; Rennó, MN; Netto, CD; Silva, AJM; Costa, PRR; Souza, W; Seabra, SH; Damatta, RA. Further evidence that naphthoquinone inhibits Toxoplasma gondii growth in vitro. Parasitology International (Print), 64, 622-631, 2015.

Roberto Takashi Sudo

• Ferreira Filho, CM; Silva AMS; Sudo, RT; Takiya CM; Machado JC. Laceration in the rat gastrocnemius. Following-up muscle repairing by ultrasound biomicroscopy (in vivo, contractility test (ex vivo) and histopathology. Acta Cirúrgica Brasileira (Impresso), 30, 13-23, 2015.

• Silva, TF; Bispo Júnior, W; Alexandre-Moreira, MS; Costa, FN; Monteiro, C; Ferreira, FF; Barroso, RCR; Noël, FG; Sudo, RT; Zapata-Sudo, G; Lima, LM; Barreiro, EJ. Novel orally active analgesic and anti-inflammatory cyclohexyl-n-acylhydrazone derivatives. Molecules (Basel. Online), 20, 3067-3088, 2015.

• Moura, VJG; Alencar, AKN; Calasans-Maia, JA; Silva, JS; Fraga, CAM; Zapata-Sudo, G; Barreiro, EJ; Sudo, RT. Novel agonist of adenosine receptor induces relaxation of corpus cavernosum in guinea pigs: an in vitro and in vivo study. Urology (Ridgewood, N.J.), 85, 1214.e17-1214.e21, 2015.

• M, CES; Nascimento-Júnior, NM; Trachez, MM; Tesch, R; Mendes, TCF; Fraga, CAM; Santanna, CM; G; Barreiro, EJ; Sudo, RT. Prevention and reversal of morphine-induced tolerance by novel muscarinic receptor agonist in rats with neuropathic pain. Journal of Neurology and Neurophysiology, 6, 1-7, 2015.

• Marques, A; Pereira, SL; Cavalcante, C; Sudo, RT; Sudo, SZ; Kaplan, MAC; Zapata-Sudo, G. Hypoglycemic effect of the methanol flower extract of Piper claussenianum and the major constituent 2,6-dihydroxy-4-methoxychalcone in streptozotocin diabetic rats. Indian Journal of Pharmaceutical Science, 77, 237-243, 2015.

• Sudo, RT; NetoML; Monteiro, CES; Amaral, RV; Resende, AC; Souza, PJC; G; Moura, RS. Antinociceptive effects of hydroalcoholic extract from Euterpe oleracea Mart. (Açaí) in a rodent model of acute and neuropathic pain. BMC Complementary and Alternative Medicine (Online), 15, 1-8, 2015.

• Muzi, H; Souza, AM; Bezerra, CGP; Boldrini, LC; Takiya, CM; Oliveira, FL; Nesi, RT; Valença, SS; Silva, AMS; Zapata-Sudo, G; Sudo, RT; Einicker-Lamas, M; Vieyra, A; Morcillo, LSL; Cunha, VMN. Rats undernourished in utero have altered Ca²⁺ signaling and reduced fertility in adulthood. Physiological Reports, 3, e12587, 2015.

Stefan Laufer

• Hennig, S; Zahn, S; Schall, C; Sievers-Engler, A; Ansideri, F; Koch, P; Lämmerhofer, M; Stehle, T; Laufer, S; Boeckler, F. targeting the gatekeeper met146 of c-JUN n-terminal kinase 3 (JNK3) induces a bivalent halogen/chalcogen bond. Journal of the American Chemical Society, 30, 2015.

• Sabatini, S; Manfroni, G; Barreca, ML; Bauer, SM; Gargaro, M; Cannalire, R; Astolfi, A; Brea, J; Vacca, C; Pirro, M; Massari, S; Tabarrini, O; Loza, MI; Fallarino, F; Laufer, S; Cecchetti, V. The pyrazolobenzothiazine core as a new chemotype of p38 alpha mitogen-activated protein kinase inhibitors. Chemical Biology & Drug Design, 86, 531-545, 2015.

• Briglia, M; Calabró, S; Signoretto, E; Laufer, S; Faggio, C, Lang, F. Fucoxanthin induced suicidal death of human erythrocytes. Cellular Physiology and Biochemistry, accepted.

• Elgokha, A; Laufer, S; Koch, P. An optimized and versatile synthesis to pyridinylimidazole-type p38α mitogen activated protein kinase inhibitors. Organic and Biomolecules Chemistry, 13, 10699–10704, 2015.

• Taves, S; Berta, T; Gan, S; Chen, G; Kim, YH; Van de Ven, T; Laufer, S; Ji, RR. Spinal inhibition of p38 MAP kinase reduces inflammatory and neuropathic pain in male but not female mice: sex-dependent microglial signaling in the spinal cord. Brain, Behavior, and Immunity, accepted

• Briglia, M; Fazio, A; Faggio, C; Laufer, S; Alzoubi, K; Lang, F. Triggering of suicidal erythrocyte death by ruxolitinib. Cellular Physiology and Biochemistry, 2015MS532, accepted

• Koeberle, A; Pergola, C; Shindou, H; Koeberle, SC; Shimizu, T; Laufer, S; Werz, O. Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with endoplasmic reticulum homeostasis. FASEB Journal, 29, 2439-2449, 2015.

• Calabrò, S; Alzoubi, K; Faggio, C; Laufer, S; Lang, L. Triggering of suicidal erythrocyte death following boswellic acid exposure. Cell Physiology and Biochemistry, 37, 131-142, 2015.

• Fehr, S; Unger, A; Schaeffeler, E; Herrmann, S; Laufer, S; Schwab, M; Albrecht, W. Impact of p38 MAP kinase inhibitors on LPS-induced release of TNF-α in whole blood and primary cells from different species. Cellular Physiology and Biochemistry, 36, 2237-2249, 2015.

• Juchum, M; Guenther, M; Laufer, S. Fighting cancer drug resistance: Opportunities and challenges for mutation-specific EGFR inhibitors. Drug Resistance Updates, 20, 12–28, 2015.

• Gehringer, M; Muth, F; Koch, P, Laufer, S. JNK inhibitors: a patent review (2010-2014). Expert Opinion on Therapeutic Patents, 25, 849-872, 2015.

• Koschitzky, IV; Gerhardt, H; Lämmerhofer, M; Kohout, M; Gehringer, M; Laufer, S; Pink, M; Schmitz-Spahnke, S; Strube, C; Kaiser, A. New insights into novel inhibitors against deoxyhypusine hydroxylase from Plasmodium falciparum: compounds with an iron chelating potential. Amino Acids, 47, 1155-1166, 2015.

• Yan, J; Schmid, E; Almilaji, A; Shumilina, E; Borst, O; Laufer, S; Gawaz, M; Lang, F. Effect of TGFβ on calcium signaling in megakaryocytes. Biochemical and Biophysical Research Communications, 461, 8-13, 2015.

• Ribeiro, D; Freitas, M; Tomé, SM; Silva, MAS; Laufer, S; Lima, JLFC; Fernandes, E. Flavonoids inhibit COX-1 and COX-2 enzymes and cytokine/chemokine production in human whole blood. Inflammation, 38, 858-870, 2015.

• Luo, D; Fajol, A; Umbach, AT; Noegel, AA; Laufer, S; Lang, F; Foeller, M. Influence of annexin A7 on insulin sensitivity of cellular glucose uptake. Pflugers Archives-European Journal of Physiology, 467, 641-649, 2015.

• Gehringer, M; Forster, M; Laufer, S. Solution-phase parallel synthesis of ruxolitinib-derived Janus kinase inhibitors via copper-catalyzed azide-alkyne cycloaddition. ACS Combinatorial Science, 17, 5-10, 2015.

• [334] Koch, P; Gehringer, M; Laufer, SA. Inhibitors of c Jun N terminal kinases: an update.Journal of Medicinal Chemistry, 58, 72-95, 2015.

• Muth, F; Günther, M; Bauer, SM; Döring, E; Fischer, S; Maier, J; Drückes, P; Köppler, J; Trappe, J; Rothbauer, U; Koch, P; Laufer, S. Tetra-substituted pyridinylimidazoles as dual inhibitors of p38α mitogen-activated protein kinase and c JUN n terminal kinase 3 for potential treatment of neurodegenerative diseases. Journal of Medicinal Chemistry, 58, 443-456, 2015.

• Freitag, A; Prajwal, P; Shymanets, A; Harteneck, C; Nürnberg, B; Schächtele, C; Kubbutat, M; Totzke, F; Laufer, S. Development of first lead structures for phosphoinositide 3 kinase-c2γ inhibitors. Journal of Medicinal Chemistry, 58, 212-222, 2015.

Valéria do Monti Nascimento Cunha

• Ayres, R; Feijó, PRO; Cintra, ACO; Tomaz, MA; Melo, PA; Cunha, VMN; Quintas, LEM. Different effects of myotoxins bothropstoxin-I and II from Bothrops snake venom on cation transport ATPases from murine fast twitch skeletal muscle. Toxicon (Oxford), 03, 80-84, 2015.

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