« 2011 | 2013 »

Carlos Alberto Manssour Fraga

• Rodrigues, APC; Costa, LM; Santos, BLR; Maia, RC; Miranda, ALP; Barreiro, EJ; Fraga, CAM. Novel furfurylidene N-acylhydrazones derived from natural safrole: discovery of LASSBio-1215, a new potent antiplatelet prototype. Journal of Enzyme Inhibition and Medicinal Chemistry (Print), 27, 101-109, 2012.

• Braga, RC; Alves, VM; Fraga, CAM; Barreiro, EJ; Oliveira, V; Andrade, CH. Combination of docking, molecular dynamics and quantum mechanical calculations for metabolism prediction of 3,4-methylenedioxybenzoyl-2-thienylhydrazone. Journal of Molecular Modeling (Online), 18, 2065-2078, 2012.

• Danuello, A; Romeiro, NC; Giesel, GM; Pivatto, M; Viegas Jr, C; Verli, H; Barreiro, EJ; Fraga, CAM; Castro, NG; Bolzani, VS. Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors. Journal of the Brazilian Chemical Society (Impresso), 23, 163-170, 2012.

• Veloso, MP; Romeiro, NC; Silva, GMS; Alves, HM; Doriguetto, AC; Ellena, J; Miranda, ALP; Barreiro, EJ; Fraga, CAM. Synthesis and characterization of the atropisomeric relationships of a substituted N-phenyl-bipyrazole derivative with anti-inflammatory properties. Chirality (New York, N.Y. Print), 24, 463-470, 2012.

• Leal, CM; Pereira, SL; Kummerle, AE; Leal, DM; Tesch, R; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G . Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor. European Journal of Medicinal Chemistry, 55, 49-57, 2012.

• Carvalho, SD; Silva, EF; Fraga, CAM; Wardell, SMSV; Wardell, JL; Tiekink, ERT. (2E)-N'-[(E)-Benzylidene]-3-phenylprop-2-enohydrazide from synchrotron radiation. Acta Crystallographica. Section E, E68, o2255-o2256, 2012.

• Maia, RC; Tesch, R; Fraga, CAM. Phenylpiperazine derivatives: a patent review (2006-present). Expert Opinion on Therapeutic Patents, 22, 1169-1178, 2012.

• Lacerda RB; Silva LL; Lima, CKF; Miguez, E; Miranda, ALP; Laufer, S; Barreiro, EJ; Fraga, CAM. Discovery of novel orally active anti-inflammatory N-phenylpyrazolyl-N-glycinylhydrazone. Plos One, 7, e46925, 2012.

• Kümmerle, AE; Schmitt, M; Cardozo, SVS; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CAM; Bourguignon, JJ; Barreiro, EJ. Design, synthesis, and pharmacological evaluation of n -acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry, 55, 7525-7545, 2012.

• Carvalho, SD; Feitosa, LO; Soares, M; Costa, TEMM; Henriques, MG ; Salomão, K; Castro, SL; Kaiser, M; Brun, R; Wardell, JL; Wardell, SMSV; Trossini, GHG; Andricopulo, AD; Silva, EF; Fraga, CAM. Design and synthesis of new (E)-Cinnamic N-Acylhydrazones as potent Antitrypanosomal agents. European Journal of Medicinal Chemistry, 54, 512-521, 2012.

Didier Jean Jacques Salmon

• Santos, GRRM; Nepomuceno-Silva, JL; Melo, LDB; Meyer-Fernandes, JR; Salmon, D; Azevedo-Pereira, RL; Lopes, UG. The GTPase TcRjl of the human pathogen Trypanosoma cruzi is involved in the cell growth and differentiation. Biochemical and Biophysical Research Communications (Print), 419, 38-42, 2012.

• Salmon, D; Bachmaier, S; Krumbholz, C; Kador, M; Gossmann, JA; Uzureau, P; Pays, E; Boshart, M. Cytokinesis of Trypanosoma brucei bloodstream forms depends on expression of adenylyl cyclases of the ESAG4 or ESAG4-like subfamily. Molecular Microbiology (Print), 84, 225-242, 2012.

• Salmon, D; Vanwalleghem, G; Morias, Y; Denoeud, J; Krumbholz, C; Lhomme, F; Bachmaier, S; Kador, M; Gossmann, J; Dias, FBS; Muylder, G; Uzureau, P; Magez, S; Moser, M; De Baetselier, P; Van Den Abbeele, J; Beschin, A; Boshart, M; Pays, E. Adenylate cyclases of Trypanosoma brucei inhibit the innate immune response of the host. Science (New York, N.Y.), online, online-online, 2012.

Eliezer Jesus de Lacerda Barreiro

• Rodrigues, APC; Costa, LMM; Santos, BLR; Maia, RC; Miranda, ALP; Barreiro, EJ; Fraga, CAM. Novel furfurylidene N-acylhydrazones derived from natural safrole: discovery of LASSBio-1215, a new potent antiplatelet prototype. Journal of Enzyme Inhibition and Medicinal Chemistry (Print), 27, 101-109, 2012.

• Hernández, P; Cabrera, M; Lavaggi, ML; Celano, L; Tiscornia, I; Costa, TR; Thomson, L; Bollati-Fogolín, M; Miranda, ALP; Lima, LM; Barreiro, EJ; González, M; Cerecetto, H. Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives. Bioorganic & Medicinal Chemistry (Print), 20, 2158-2171, 2012.

• Lacerda, RB; Silva, LL; Lima, CKF; Miguez, E; Miranda, ALP; Laufer, SA; Barreiro, EJ; Fraga, CAM . Discovery of novel orally active anti-inflammatory n-phenylpyrazolyl-n-glycinyl-hydrazone derivatives that inhibit TNF-α production. Plos One, 7, e46925, 2012.

• Kümmerle, AE; Schmitt, M; Cardozo, SVS; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CAM; Bourguignon, JJ; Barreiro, EJ . Design, synthesis, and pharmacological evaluation of n -acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry, 55, 7525-7545, 2012.

• Zapata-Sudo, G; Lima, LM; Barreiro, EJ; Nunes, IKC; Pontes, LB; Silva, JS; Barreiro, EJ; Sudo, RT; Lima, LM. Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model. European Journal of Pharmacology, 690, 176-182, 2012.

• Leal, CM; Pereira, SL; Kümmerle, AE; Leal, DM; Tesch, R; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor. European Journal of Medicinal Chemistry, 55, 49-57, 2012.

• Veloso, MP; Barreiro, EJ; Miranda, ALP; Silva, GMS; Doriguetto, AC; Romeiro, NC; Ellena, J; Fraga, CAM; Alves, HM. Synthesis and characterization of the atropisomeric relationships of a substituted N-phenyl-bipyrazole derivative with anti-inflammatory properties. Chirality (New York, N.Y. Print), 24, 463-470, 2012.

• Menezes, CMS; Alves, MA; Amaral, DN; Noël, F; Rivera, G ; Barreiro, EJ; Lima, LM; Thibaut, JPB . Synthesis, biological evaluation, and structure-activity relationship of clonazepam, meclonazepam, and 1,4-benzodiazepine compounds with schistosomicidal activity. Chemical Biology & Drug Design (Print), 79, 943-949, 2012.

• Danuello, A; Romeiro, NC; Giesel, GM; Pivatto, M; Viegas Junior, C; Verli, H; Barreiro, E. J; Fraga, CAM; Castro, NG; Bolzani, VS. Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors. Journal of the Brazilian Chemical Society (Impresso), 23, 163-170, 2012.

• Neves, G; Antonio, CB; Betti, AH; Pranke, MA; Fraga, CAM; Barreiro, EJ; Noël, F; Rates, SMK. New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia. Behavioural Brain Research, 86-95, 2012.

• Miranda, A; Júnior, W; Silva, Y; Alexandre-Moreira, M; Castro, R; Sabino, J; Lião, L; Lima, LM; Barreiro, EJ. Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues. Molecules (Basel. Online), 17, 14126-14145, 2012.

• Barbosa, M; Ramos, T; Arantes, A; Martins, MA; Silva, P; Barreiro, EJ; Lima, LM. Synthesis and pharmacological evaluation of novel phenyl sulfonamide derivatives designed as modulators of pulmonary inflammatory response. Molecules (Basel. Online), 17, 14651-14672, 2012.

• Martins, MV; Estevam, CS; Santos, ALLM; Dias, AS; Cupertino-da-Silva, YK; Araújo-Júnior, JX; Miranda, ALP; Barreiro, EJ; Pizza, C; Piacente, S; Montoro, P; Quintans-Júnior, LJ; Araujo, BS; Alexandre-Moreira, MS; Sant'ana, AEG . Antinociceptive effects of an extract, fraction and an isolated compound of the stem bark of Maytenus rigida. Revista Brasileira de Farmacognosia (Impresso), 22, p 598-603, 2012.

• Lopes, RO; Romeiro, NC; Lima, CKF; Silva, LL; Miranda, ALP; Nascimento, PGBD; Cunha, FQ; Barreiro, EJ; Lima, LM. Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors. European Journal of Medicinal Chemistry, 54, 264-271, 2012.

• Ribeiro, JCML; Fechine, FV; Ribeiro, MZML; Barreiro, EJ; Lima, LM; Ricardo, NMPS; Moraes, MEA; Moraes, MO. Potential inhibitory effect of LASSBio-596, a new thalidomide hybrid, on inflammatory corneal angiogenesis in rabbits. Ophthalmic Research, 48, 177-185, 2012.

Floriano Paes Silva Junior

• Trevizano, LM; Ventorim, RZ; Rezende, ST; Junior, FPS; Guimarães, VM. Thermostability improvement of Orpinomyces sp. xylanase by directed evolution. Journal of Molecular Catalysis. B, Enzymatic (Print), 81, 12-18, 2012.

• Senger, MR; Gomes, LCA; Ferreira, SB; Kaiser, CR; Ferreira, VF; Silva-Jr, FP. Kinetics studies on the inhibition mechanism of pancreatic α-amylase by glycoconjugated 1h-1,2,3-triazoles: a new class of inhibitors with hypoglycemiant activity. ChemBioChem (Print), 13, 1584-1593, 2012.

• Beghini, DG; Ferreira, ATS; Almeida, VC; Caminha, MA; Silva-Jr, FP; Perales, J; Menna-Barreto, RFS. New insights in Trypanosoma cruzi proteomic map: further post-translational modifications and potential drug targets in Y strain epimastigotes. Journal of Integrated OMICS, 2, 2012.

François Germain Noel

• Arnaud-Batista, FJ; Costa, GT; Oliveira, IMB; Costa, PPC; Santos, CF; Fonteles, MC; Uchoa, DE; Silveira, ER; Cardi, BA; Carvalho, KM; Amaral, LS; Poças, ES C; Quintas, LEM; Noel, F; Nascimento, NRF. The natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na+/K+-ATPase-Src kinase pathway. American Journal of Physiology. Renal Physiology, F959-F966, 2012.

• Menezes, CMS; Rivera, G; Alves, MA; Amaral, DN; Thibaut, JPB; Noël, F; Barreiro, EJ; Lima, LM. Synthesis, biological evaluation, and structure-activity relationship of clonazepam, meclonazepam, and 1,4-benzodiazepine compounds with schistosomicidal activity. Chemical Biology & Drug Design (Print), 79, 943-949, 2012.

• Neves, G; Antonio, CB; Betti, AH; Pranke, MA; Fraga, CAM; Barreiro, EJ; Noël, F; Rates, SMK. New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia. Behavioural Brain Research, 62, 86-95, 2012.

Gilda Angela Neves

• Garcia, CSC; Ely, MR; Wasum, RA; Zoppas, BCA; Wollheim, C; Neves, G; Weiss-Angeli, V; Souza, KCB. Assessment of Salvia officinalis (L.) hydroalcoholic extract for possible use in cosmetic formulation as inhibitor of pathogens in the skin. Revista de Ciências Farmacêuticas Básica e Aplicada, 33, 509-514, 2012.

Gisele Zapata Sudo

• Peçanha, R; Bagno, LLS; Ribeiro, MB; Ferreira, ABR; Moraes, MO; Zapata-Sudo, G; Kasai-Brunswick, TH; Carvalho, ACC; Goldenberg, RCS; Werneck-de-Castro, JPS. Adipose-derived stem-cell treatment of skeletal muscle injury. journal of bone and joint surgery. American Volume (Print ed.), 94, 609-617, 2012.

• Pontes, LB; Antunes, F; Sudo, RT; Raimundo, JM; Lima, LM; Barreiro, EJ; Zapata-Sudo, G. Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound. Fundamental & Clinical Pharmacology, 26, 690-700, 2012.

• Zapata-Sudo, G; Pontes, LB; Silva, JS; Lima, LM; Nunes, IK; Barreiro, EJ; Sudo, RT. Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model. European Journal of Pharmacology, 690, 176-182, 2012.

• Leal, CM; Pereira, SL; Kümmerle, AE; Leal, DM; Tesch, R; Sant’Anna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Antihypertensive profile of 2-thienyl-3,4-methylenedioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor. European Journal of Medicinal Chemistry, 55, 49-57, 2012.

• P; Souza, BJ; Monteiro, CES; Romeiro, NC; D'Andrea, ED; Sudo, RT; Barreiro, EJ. Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designed as PPAR-gamma agonists. Current Topics in Medicinal Chemistry (Print), 12, 2037-2048, 2012.

Josiane Sabbadini Neves

• Muniz, VS; Weller, PF; Neves, J. Eosinophil crystalloid granules: structure, function, and beyond. Journal of Leukocyte Biology, 92, 281-288, 2012.

Lidia Moreira Lima

• Hernández, P; Cabrera, M; Lavaggi, ML; Celano, L; Tiscornia, I; Costa, TR; Thomson, L; Bollati-Fogolín, M; Miranda, ALP; Lima, LM; Barreiro, EJ; González, M; Cerecetto, H. Discovery of new orally effective analgesic and anti-inflammatory hybrid furoxanyl N-acylhydrazone derivatives. Bioorganic & Medicinal Chemistry (Print), 20, 2158-2171, 2012.

• Menezes, CMS; Rivera, G; Alves, MA; Amaral, DN; Thibaut, JPB; Noël, F; Barreiro, EJ; Lima, LM. Synthesis, biological evaluation, and structure-activity relationship of clonazepam, meclonazepam, and 1,4-benzodiazepine compounds with schistosomicidal activity. Chemical Biology & Drug Design (Print), 79, 943-949, 2012.

• Ribeiro, JCML; Fechine, FV; Ribeiro, MZML; Barreiro, EJ; Lima, LM; Ricardo, NMPS; Moraes, MEA; Moraes, MO. Potential inhibitory effect of LASSBio-596, a new thalidomide hybrid, on inflammatory corneal angiogenesis in rabbits. Ophthalmic Research, 48, 177-185, 2012.

• Carvalho, DS; Lima, LM; Barreiro, EJ; Alves, TR; Nery, JAC; Sarno, EN; Sampaio, EP. LASSBio-542: novel thalidomide analog distinctly modulates il-10 and inhibits angiogenesis. Current Bioactive Compounds, 8, 167-175, 2012.

• Zapata-Sudo, G; Pontes, LB; Silva, JS; Lima, LM; Nunes, IKC; Barreiro, EJesus; Sudo, RT. Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model. European Journal of Pharmacology, 690, 176-182, 2012.

• Lopes, RO; Romeiro, NC; Lima, CKF; Silva, LL; Miranda, ALP; Nascimento, PGBD; Cunha, FQ; Barreiro, EJ; Lima, LM. Docking, synthesis and pharmacological activity of novel urea-derivatives designed as p38 MAPK inhibitors. European Journal of Medicinal Chemistry, 54, 264-271, 2012.

• Miranda, A; Júnior, W; Silva, Y; Alexandre-Moreira, M; Castro, R; Sabino, J; Lião, L; Lima, LM; Barreiro, EJ. Design, synthesis, antinociceptive and anti-inflammatory activities of novel piroxicam analogues. Molecules (Basel. Online), 17, 14126-14145, 2012.

• Barbosa, MLC; Ramos, TJF; Arantes, ACS; Martins, MA; Silva, PMR; Barreiro, EJ; Lima, LM. Synthesis and pharmacological evaluation of novel phenyl sulfonamide derivatives designed as modulators of pulmonary inflammatory response. Molecules (Basel. Online), 17, 14651-14672, 2012.

• Zapata-Sudo, G; Lima, LM; Pereira, S; Trachez, MM; Costa, FP; Souza, BJ; Monteiro, CES; Romeiro, NR; D'andrea, ED; Sudo, RT; Barreiro, EJ. Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designed as PPAR-gamma agonists. Current Topics in Medicinal Chemistry (Print), 12, 2037-2048, 2012.

Lucienne da Silva Lara Morcillo

• Ferrao, FM; Lara, LS; Axelband, F; Dias, J; Carmona, AK; Reis, RI; Costa-Neto, CM; Vieyra, A; Lowe, J. Exposure of luminal membranes of LLC-PK1 cells to ANG II induces dimerization of AT1/AT2 receptors to activate SERCA and to promote Ca2+ mobilization. American Journal of Physiology. Renal Physiology, 302, F875-F883, 2012.

• Axelband, F; Dias, J; Miranda, F; Ferrão, FM; Reis, RI; Costa-Neto, CM; Lara, LS, Vieyra, A. Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway. Regulatory Peptides (Print), 177, 27-34, 2012.

• Lara, LS; Satou, R; Bourgois, CR; Gonzalez AA; Zsombok A; Prieto MC; Navar LG. The sodium-activated sodium channel is expressed in the rat kidney thick ascending limb and collecting duct cells and is upregulated during high salt intake. American Journal of Physiology. Renal Physiology, 303, F105-F109, 2012.

Luis Eduardo Menezes Quintas

• Arnaud-Batista, FJ; Costa, GT; Oliveira, IMB; Costa, PPC; Santos, CF; Fonteles, MC; Uchoa, DE; Silveira, ER; Cardi, BA; Carvalho, KM; Amaral, LS; Pocas, ESC; Quintas, LEM; Noel, F; Nascimento, NRF. The natriuretic effect of bufalin in isolated rat kidneys involves activation of the Na⁺/K⁺-ATPase-Src kinase pathway. American Journal of Physiology. Renal Physiology, 1, 1-F966, 2012.

• Lucas, TFG; Amaral, LS; Porto, CS; Quintas, LEM. Na⁺/K⁺-ATPase 1 isoform mediates ouabain-induced expression of cyclin D1 and proliferation of rat Sertoli cells. Reproduction (Cambridge), 144, 737-745, 2012.

Luzineide Wanderley Tinoco

• Adão, CR; Silva, BP; Tinoco, LW; Parente, JP. Haemolytic activity and immunological adjuvant effect of a new steroidal saponin from Allium ampeloprasum var. porrum. Chemistry & Biodiversity (Print), 9, 58-67, 2012.

• Coutinho, MAS; Muzitano, MF; Cruz, EA; Bergonzi, MC; Kaiser, CR; Tinoco, LW; Bilia, A R; Vincieri, FA; Rossi-Bergmann, B; Costa, SS. Flowers from Kalanchoe pinnata are a rich source of t cell-suppressive flavonoids. Natural Product Communications, 7, 1-4, 2012.

• Merlino, A; Benitez, D; Campillo, NE; Páez, JA; Tinoco, LW; González, M; Cerecetto, H. Amidines bearing benzofuroxan or benzimidazole 1,3-dioxide core scaffolds as Trypanosoma cruzi-inhibitors: structural basis for their interactions with cruzipain. Medchemcomm, 3, 90-101, 2012.

• Camargo, LMM; Férézou, JP; Tinoco, LW; Kaiser, CR; Costa, SS. Flavonoids from Mimosa xanthocentra (Leguminosae: Mimosoideae) and molecular modeling studies for isovitexin-2--O-α-l-rhamnopyranoside rotamers. Phytochemistry Letters (Print), 5, 427-431, 2012.

• Rennó, MN; França, Costa, TC; Nico, D; Palatnik-de-Sousa, CB; Tinoco, LW; Figueroa-Villar, JD. Kinetics and docking studies of two potential new inhibitors of the nucleoside hydrolase from Leishmania donovani. European Journal of Medicinal Chemistry, 56, 301-307, 2012.

• Alvarez, G; Aguirre-López, B; Cabrera, N; Marins, EB; Tinoco, LW; Batthyány, I; de Gómez-Puyou, MT; Puyou, AG; Pérez-Montfort, R; Cerecetto, H; González, M. 1,2,4-thiadiazol-5(4 H )-ones: a new class of selective inhibitors of Trypanosoma cruzi triosephosphate isomerase. Study of the mechanism of inhibition. Journal of Enzyme Inhibition and Medicinal Chemistry (Print), 28, 1-9, 2012.

Marco Aurélio Martins

• Marinho, DG; Alviano, DS; Matheus, ME; Alviano, CS; Fernandes, PD. The latex obtained from Hancornia speciosa Gomes possesses anti-inflammatory activity. Journal of Ethnopharmacology, 135, 530-537, 2011.

• Santos, RL; Lacerda, MCM; Goncalves, RT; Martins, MA; Souza, MMG. Immunosuppressants: Implications in Orthodontics. Dental Press Journal of Orthodontics, 17, 55-61, 2012.

• Bezerra-Santos, ClR; Souza, HS; Pires, AL; Bandeira-Melo, C; Barbosa-Filho, JM; Vieira-de-Abreu, A; Piuvezam, MR; Vieira, GC; Filho, JR; Bozza, PT; Martins, MA. Effectiveness of Cissampelos sympodialis and its isolated alkaloid warifteine in airway hyperreactivity and lung remodeling in a mouse model of asthma. International Immunopharmacology (Print), 13, 148-155, 2012.

• Barbosa, M; Ramos, T; Arantes, A; Martins, MA; Silva, PMR; Barreiro, EJ; Lima, LM. Synthesis and pharmacological evaluation of novel phenyl sulfonamide derivatives designed as modulators of pulmonary inflammatory response. Molecules (Basel. Online), 17, 14651-14672, 2012.

• Olsen, PC; Silva, PMR; Costa, JCS; Martins, MA; Cordeiro, RSB; Coelho, LP. Two for one: Cyclic AMP mediates the anti-inflammatory and anti-spasmodic properties of the non-anesthetic lidocaine analog JMF2-1. European Journal of Pharmacology, 680, 102-107, 2012.

• Olsen, PC; Martins, MA. Anti-inflammatory medication beyond glucocorticoids for asthma therapy: role of leukotriene modifiers, mast cell stabilizers and other perspectives. Pulmão RJ, 21, 65-69, 2012.

• Kümmerle, AE; Schmitt, M; Cardozo, SVS; Lugnier, C; Villa, P; Lopes, AB; Romeiro, NC; Justiniano, H; Martins, MA; Fraga, CAM; Bourguignon, JJ; Barreiro, EJ. Design, synthesis, and pharmacological evaluation of n -acylhydrazones and novel conformationally constrained compounds as selective and potent orally active phosphodiesterase-4 inhibitors. Journal of Medicinal Chemistry, 55, 7525-7545, 2012.

• Serra, MF; Anjos-Valotta, EA; Olsen, PC; Couto, GC; Jurgilas, P; Cotias, AC; Pao, CRR; Ferreira, TPT; Arantes, ACS; Pires, ALA; Cordeiro, RSB; Silva, PMRE; Martins, MA. Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. Anesthesiology (Philadelphia), Sep.117, 580-591, 2012.

• Torres, RC; Batista, Marcelo, M; Pons, AH; Silva, AR; Cordeiro, RSB ; Martins, MA; Silva, PMR; Carvalho, VF. Activation of PPARγ by restores mast cell numbers and reactivity in alloxan-diabetic rats by reducing the systemic glucocorticoid levels. European Journal of Pharmacology, 691, 261-267, 2012.

Marília Zaluar Passos Guimarães

• Pamplona, FA ; Ferreira, J; Lima, OM; Duarte, FS; Bento, AF; Forner, S; Villarinho, JG; Bellochio, L; Wotjak, CT; Lerner, R; Monory, K; Lutz, B; Canetti, C; Matias, I; Calixto, JB; Marsicano, G; Guimaraes, MZP; Takahashi, RN. Anti-inflammatory lipoxin A4 is an endogenous allosteric enhancer of CB1 cannabinoid receptor. Proceedings of the National Academy of Sciences of the United States of America (Online), 109, 21134-21139, 2012.

Newton Gonçalves de Castro

• Paulsen, BS; Maciel, RM; Galina, A; da Silveira, MS; Souza, CS; Drummond, H; Pozzatto, EN; Silva Junior, H; Chicaybam, L; Massuda, R; Setti-Perdigão, Pedro;Bonamino, MH; Belmonte-de-Abreu, PS; Castro, NG; Brentani, H; Rehen, S . Altered oxygen metabolism associated to neurogenesis of induced pluripotent stem cells derived from a schizophrenic patient. Cell Transplantation, 21, 1547-1559, 2012.

• Danuello, A; Romeiro, NC; Giesel, GM; Pivatto, M; Viegas Jr, C; Verli, H; Barreiro, EJ; Fraga, CAM; Castro, NG; Bolzani, VS. Molecular docking and molecular dynamic studies of semi-synthetic piperidine alkaloids as acetylcholinesterase inhibitors. Journal of the Brazilian Chemical Society (Impresso), 23, 163-170, 2012.

• Diniz, LP; Almeida, JC; Tortelli, V; Lopes, CV; Setti-Perdigão, P; Stipursky, J; Kahn, SA; Romao, LF; Miranda, J; Alves-Leon, SV; Souza, JM; Castro, NG; Panizzutti, R; Gomes, FCA. Astrocyte-induced synaptogenesis is mediated by transforming growth factor signaling through modulation of d-serine levels in cerebral cortex neurons. Journal of Biological Chemistry (Online), 287, 41432-41445, 2012.

Nubia Boechat

• Boechat, N; Magalhães JL; Antunes, A . Internalização de farmoquímicos e medicamentos para doenças tropicais negligenciadas: proposta de interação entre Governo - Universidade - Empresa. Química Nova (Impresso), 35, 654-660, 2012.

• Magalhães JL; Boechat, N; Antunes, A . Identification of Brazilian expertise in the fight against some neglected tropical diseases. Revista da Sociedade Brasileira de Medicina Tropical (Impresso), 45, 415-417, 2012.

• Bastos, MM; Boechat, N; Gomes, ATPC; Neves, MGPM; Cavaleiro, JAS. O Uso de Porfirinas em Terapia Fotodinâmica no Tratamento da Leishmaniose Cutânea. Revista Virtual de Química, 4, 257-267, 2012.

• Santos-Filho, OA; Forge, D; Hoelz, LVB; Freitas, GBL; Marinho, TO; Araújo, JQ; Albuquerque, MG; Alencastro, RB;Boechat, N. CoMFA/CoMSIA 3D-QSAR of pyrimidine inhibitors of Pneumocystis carinii dihydrofolate reductase. Journal of Molecular Modeling, 2012, on line-on line, 2012.

• Boechat, N; Ferreira, MLG; Bastos, MM; Silva, GP; Wardell, SMSV; Wardell, J. Structures of 1-(substituted-phenyl)-4-hydroxymethyl- and -4-fluoromethyl-1,2,3-triazoles. Zeitschrift fur Kristallographie, 227, 369-378, 2012.

• Boechat, N; Branco, FSC; Pinto, AC. A Química Medicinal de Novas Moléculas em Fase Clínica para o Tratamento da Tuberculose. Revista Virtual de Química, 4, 287-328, 2012.

• Boechat, N; Pinheiro, LCS. A Hanseníase e a sua Quimioterapia. Revista Virtual de Química, 4, 247-256, 2012.

• Boechat, N; Pinheiro, LCS; Silva, TS; Aguiar, AC; Carvalho, AS; Bastos, MM; Costa, CC P; Pinheiro, S; Pinto, AC; Mendonca, JS; Dutra, KDB; Valverde, AL; Santos-Filho, OA; Krettli, AU. New trifluoromethyl triazolopyrimidines as anti-Plasmodium falciparum agents. Molecules (Basel. Online), 17, 8285-8302, 2012.

• Wollinger, W; Lessa, BM; Nobrega, AB; Riente, RR; Sabatini, R; Lopes, CC; Boechat, N; Slana, GBCA. Simultaneous determination of assay and related substances in nevirapine suspension by HPLC. Chromatographia (Wiesbaden), 75, 893-901, 2012.

Patricia Dias Fernandes

• Radulovic, N; Nevenka, O; Marija, D; Pinheiro, MMG; Fernandes, PD; Boylan, F. A novel toxic alkaloid from poison hemlock (Conium maculatum L., Apiaceae): Identification, synthesis and antinociceptive activity. Food and Chemical Toxicology, 50, 274-279, 2012.

• Pinheiro, MMF; Boylan, F; Fernandes, PD. Antinociceptive effect of the Orbignya speciosa Mart. (Babassu) leaves: Evidence for the involvement of apigenin. Life Sciences (1973), 91, 293-300, 2012.

• Rangel, RAS; Marinho, BG; Fernandes, PD; Moura, RS; Lessa, MA. Pharmacological mechanisms involved in the antinociceptive effects of dexmedetomidine in mice. Fundamental & Clinical Pharmacology, 01, 00-05, 2012.

• Abdul-Wahab, IR; Guilhon, CC; Fernandes, PD; Boylan, F. Anti-nociceptive activity of Pereskia bleo Kunth. (Cactaceae) leaves extracts. Journal of Ethnopharmacology, 144, 741-746, 2012.

• Amorim, JL; Pinheiro, MMG; Simões, AC; Silva, AJR; Fernandes, PD. Characterization of the anti-inflammatory effect from the essential oil of Citrus latifolia. Planta Medica, 78, 78-78, 2012.

Patrícia Machado Rodrigues e Silva Martins

• Olsen, PC; Coelho, LP; Costa, JC; Cordeiro, RSB; Silva, PMR; Martins, MA. Two for one: cyclic amp mediates the anti-inflammatory and anti-spasmodic properties of the non-anesthetic lidocaine analog JMF2-1. European Journal of Pharmacology, 680, 102-107, 2012.

• Serra, MF; Anjos-Valota, E; Olsen, PC; Couto, GC; Jurgilas, P; Cotias, AC; Pao, CRR; Ferreira, TPT; ACS, Arantes; ALA; RSB, Cordeiro; Silva PMR; Martins, MA. Nebulized lidocaine prevents airway inflammation, peribronchial fibrosis, and mucus production in a murine model of asthma. Anesthesiology (Philadelphia), 117, 580-591, 2012.

• Machado, CCP; Silva PMR; Mandarim-de-Lacerda, CA; Nojima, MCG. Histomorphometric study of periodontal ligament in the initial period of orthodontic movement in wistar rats with induced allergic asthma. American Journal of Orthodontics and Dentofacial Orthopedics, 142, 333-338, 2012.

• Torres, RC; Meuserbatista, M; Henrique-Pons, A; Silva, AR; Cordeiro, BB; Martins, MA; Silva PMR; Carvalho, VF. Activation of PPAR-gamma by rosiglitazone restores mast cell numbers and reactivity in alloxan- diabetic rats by reducing the systemic glucocorticoid levels. European Journal of Pharmacology, 691, 261-267, 2012.

• Lanzetti, M; Costa, C; Nesi, RT; Barroso, MV; Martins, V; Victoni, T; Langente, V; Pires, KM; Silva PMR; Resende, AC; Porto, LC; Benjamin, CF; Valenca, S. Oxidative and nitrosative stress are involved in different stages of proteolytic emphysema. Free Radical Biology & Medicine, 53, 1993-2001, 2012.

Paulo de Assis Melo

• Frattini, F; Lopes, FRP; Almeida, FM; Rodrigues, RF; Boldrini, LC; Tomaz, MA; Baptista, AF; Melo, PA; Martinez, AMB. Mesenchymal stem cells in a polycaprolactone conduit promote sciatic nerve regeneration and sensory neuron survival after nerve injury. tissue engineering. Part A, 18, 1-10, 2012.

• Saturnino-Oliveira, J; Tomaz, MA; Fonseca, TF; Gaban, GA; Monteiro-Machado, M; Strauch, MA; Cons, BL; Calil-Elias, S; Martinez, AMB; Melo, PA . Pulsed ultrasound therapy accelerates the recovery of skeletal muscle damage induced by Bothrops jararacussu venom. Brazilian Journal of Medical and Biological Research on line, 45, p. 488-496, 2012.

Paulo Roberto Ribeiro Costa

• Costa, FN; Silva, AJM; Netto, CD; Domingos, JLO; Costa, PRR ; Leitão, GG. Purification of a synthetic pterocarpanquinone by countercurrent chromatography. Journal of the Brazilian Chemical Society (Impresso), 23, 1114-1118, 2012.

• Portes, JA; Netto, CD; Silva, AJM; Costa, PRR; Matta, RA; Santos, TAT; Souza, W; Seabra, SH. A new type of pterocarpanquinone that affects Toxoplasma gondii tachyzoites in vitro. Veterinary Parasitology (Print), 186, 261-269, 2012.

• Mancebo-Aracil, J; Martín-Rodríguez, M; Nájera, C; Sansano, JM; Costa, PRR; Lima, EC; Dias, AG. Binap-silver salts as chiral catalysts for the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and alkenes. Tetrahedron: Asymmetry (Print), 23, 1596-1606, 2012.

• Strauch, MA; Tomaz, MA; Machado, MM; Cruz, JMT; Cons, BL; Silva, AJM; Costa, PRR; Melo, PA. Evaluation of the antiophidic activity of lapachol and synthetic analogues. Toxicon (Oxford), 60, 205-205, 2012.

Roberto Takashi Sudo

• Pontes, LB; Antunes, F; Sudo, RT; Raimundo, JM; Lima, LM; Barreiro, EJ; Zapata-Sudo, G. Vasodilatory activity and antihypertensive profile mediated by inhibition of phosphodiesterase type 1 induced by a novel sulfonamide compound. Fundamental & Clinical Pharmacology, 26, 690-700, 2012.

• Zapata-Sudo, G; Pontes, LB; Silva, JS; Lima, LM; Nunes, IK; Barreiro, EJ; Sudo, RT. Benzenesulfonamide attenuates monocrotaline-induced pulmonary arterial hypertension in a rat model. European Journal of Pharmacology, 690, 176-182, 2012.

• Leal, CM; Pereira, SL; Kummerle, AE; Leal, DM; Tesch, R; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Antihypertensive profile of 2-thienyl-3,4-methyleneddioxybenzoylhydrazone is mediated by activation of the A2A adenosine receptor. European Journal of Medicinal Chemistry, 55, 49-57, 2012.

• Zapata-Sudo, G; Lima, LM; Pereira, SL; Trachez, MM; Costa, FP; Souza, BJ; Monteiro, CES; Romeiro NC; Dandrea, ED; Sudo, RT; Barreiro, EJ. Docking, synthesis and anti-diabetic activity of novel sulfonylhydrazone derivatives designedas PPAR-gama agonists. Current Topics in Medicinal Chemistry (Print), 12, 2037-2048, 2012.

« 2011 | 2013 »