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Carlos Alberto Manssour Fraga

• Pol-Fachin, L; Fraga, CAM; Barreiro, EJ; Verli, H. Characterization of the conformational ensemble from bioactive N-acylhydrazone derivatives. Journal of Molecular Graphics & Modelling, 28, 446-454, 2010.

• Nascimento-Jr, NM; Mendes, TCF; Leal, DM; Côrrea, CMN; Sudo, RT; Zapata-Sudo, G; Barreiro, EJ; Fraga, CAM. Microwave-assisted synthesis and structure activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives. Bioorganic & Medicinal Chemistry Letters, 20, 74-77, 2010.

• Zapata-Sudo, G; Pereira, SL; Beiral, HJV; Kummerle, AE; Raimundo, JM; Antunes, F; Sudo, RT; Barreiro, EJ; Fraga, CAM. Pharmacological characterization of (3-Thienylidene)-3,4-methylenedioxybenzoylhydrazide: A novel muscarinic agonist with antihypertensive profile. American Journal of Hypertension, 23, 135-141, 2010.

• Pol-Fachin, L; Fraga, CAM; Barreiro, EJ; Verli, H. Characterization of the conformational ensemble from bioactive N-acylhydrazone derivatives. Journal of Molecular Graphics & Modelling, 28, 446-454, 2010.

• Neves, G; Menegatti, R; Antonio, CB; Grazziottin, LR; Vieira, RO; Rates, SMK; Noel, F; Barreiro, EJ; Fraga, CAM. Searching for multi-target antipsychotics: discovery of orally active heterocyclic n-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorganic & Medicinal Chemistry, 18, 1925-1935, 2010.

• Pazini, F; Menegatti, R; Sabino, JR; Andrade, CH; Neves, G; Rates, SMK; Fraga, CAM; Barreiro, EJ; Oliveira, V. Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. Bioorganic & Medicinal Chemistry Letters, 20, 2888-2891, 2010.

• Salomão, K; Souza, EM; Carvalho, SD; Silva, EF; Fraga, CAM; Barbosa, HS; Castro, SL. In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi. Antimicrobial Agents and Chemotherapy (Print), 54, 2023-2031, 2010.

• Tributino, JLM; Santos, MHL; Mesquita, CM; Lima, CKF; da Silva LL; RC; CM; Barreiro, EJ; Fraga, CAM; Castro, NG; Miranda, ALP; Guimarães, MZP. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. British Journal of Pharmacology, 159, 1716-1726, 2010.

• Brito, FCF; Kummerle, AE; Lugnier, C; Fraga, CAM; Barreiro, EJ; M, ALP. Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition. European Journal of Pharmacology, 638, 5-12, 2010.

• Carneiro, EO; Andrade, CH; Braga, RC; Tôrres, ACB; Alves, RO; Lião, LM; Fraga, CAM; Barreiro, EJ; Oliveira, V. Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294. Bioorganic & Medicinal Chemistry Letters, 20, 3734-3736, 2010.

• Costa, DG; Silva, JS; Kummerle, AAE; Sudo, RT; Landgraf, SS; Caruso-Neves, C; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G. LASSBio-294, a compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca2+ influx into sarcoplasmic reticulum after myocardial infarction. American Journal of Hypertension, 23, 1220-1227, 2010.

• Carvalho, SD; Silva, EF; Fraga, CAM; Wardell, SMSV; Wardell, JL; Tiekink, ERT. (2E)-N'-[(E)-4-Chlorobenzylidene]-3-phenylprop-2-enohydrazide monohydrate. Acta Crystallographica. Section E, 66, o2410-o2411, 2010.

• Maia, RC; Fraga, CAM. Discovery of dual chemotherapy drug candidates designed by molecular hybridization. Current Enzyme Inhibition, 6, 171-182, 2010.

• Carvalho, SD; Silva, EF; Lourenço, MCS; de Souza, MVN; Fraga, CAM. Antimycobacterial profile of 5-phenyl-1,3,4-thiadiazole-2-arylhydrazone derivatives. Letters in Drug Design & Discovery, 7, 606-609, 2010.

• Araújo-Júnior, JX; Ribeiro, EAN; Fraga, CAM; Lima, LM; Barreiro, EJ; Medeiros, IA. Cardiovascular effects induced by N-(4'-dihydro)-piperoylthiomorpholine in normotensive rats. Journal of Pharmacy and Pharmacology, 62, 1794-1800, 2010.

Cláudia Lucia Martins da Silva

• Markus, RP; Silva, CLM; Franco, DG; Barbosa Jr, EM; Ferreira, ZS. Is modulation of nicotinic acetylcholine receptors by melatonin relevant for therapy with cholinergic drugs? Pharmacology & Therapeutics (Oxford), 1, 1, 2010.

• Pimenta, PHC; Silva, CLM; Noël, F . Ivermectin is a nonselective inhibitor of mammalian P-type ATPases. Naunyn-Schmiedeberg's Archives of Pharmacology, 381, 147-152, 2010.

• Barreto, F; Rezende, DC; Scaramello, CBV; Silva, CLM; Cunha, VMN; Caricati-Neto, A; Jurkiewicz, A; Noël, F; Quintas, LEM. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors. Brazilian Journal of Medical and Biological Research on line, 43, 500-505, 2010.

Eliezer Jesus de Lacerda Barreiro

• Barreiro, EJ; Nascimento-Junior, NM; Mendes, TCF; Leal, DM; Corrêa, CMN; Sudo, RT; Zapata-Sudo, G; Fraga, CAM. Microwave-assisted synthesis and structure activity relationships of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives. Bioorganic & Medicinal Chemistry Letters (Print), 20, 74-77, 2010.

• Pol-Fachin, L; Fraga, CAM; Barreiro, EJ; Verli, H. Characterization of the conformational ensemble from bioactive N-acylhydrazone derivatives. Journal of Molecular Graphics & Modelling, 28, 446-454, 2010.

• Neves, G; Menegatti, R; Antonio, CB; Grazziottin LR; Vieira RO; Rates, SMK; Noel, FG; Barreiro, EJ; Fraga, CAM. Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorganic & Medicinal Chemistry, 18, 1925-1935, 2010.

• Pazini, F; Menegatti, R; Sabino, JR; Andrade, CH; Neves, G; Rates, SMK; Noël, F; Fraga, CarlosAM; Barreiro, EJ; Oliveira, V. Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. Bioorganic & Medicinal Chemistry Letters, 20, 2888-2891, 2010.

• Tributino, JLM; Santos, MLH; Mesquita, CM; Lima, CKF; Silva, LL; Maia, RC; Duarte, CD; Barreiro, EJ; Fraga, CAM; Castro, NG; Miranda, ALP; Guimaraes, MZP. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. British Journal of Pharmacology, 159, 1716-1723, 2010.

• Carneiro, EO; Andrade, CH; Braga, RC; Tôrres, ACB; Alves, RO; Lião, LM; Fraga, CAM; Barreiro, EJ; Oliveira, V. Structure-based prediction and biosynthesis of the major mammalian metabolite of the cardioactive prototype LASSBio-294. Bioorganic & Medicinal Chemistry Letters, 3734-3736, 2010.

• Brito, FCF; Kummerle, AE; Lugnier, C; Fraga, CAM; Barreiro, EJ; Miranda, ALP. Novel thienylacylhydrazone derivatives inhibit platelet aggregation through cyclic nucleotides modulation and thromboxane A2 synthesis inhibition. European Journal of Pharmacology, 5-12, 2010.

• Menezes, CMS; Avila, CM; Barreiro, EJ. A Theoretical Investigation on the Pleiotropic Effects of Statins as p38. Letters in Drug Design & Discovery, 7, 546-550, 2010.

• Carvalho, GMC; Oliveira, VR; Soares, RM; Azevedo, SMFO; Lima, LM; Barreiro, EJ; Valença, SS; Saldiva, PHN; Faffe, DS; Zin, WA. Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? Toxicon (Oxford), 56, 604-612, 2010.

• Silva, YKC; Augusto, CV; Barbosa, MLC; Melo, GMA; Queiroz, AC; Dias, TLMF; B, W; Barreiro, EJ; Lima, LM; Alexandre-Moreira, MS. Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates. Bioorganic & Medicinal Chemistry (Print), 18, 5007-5015, 2010.

• Araújo Jr, JX; Ribeiro EAN; Fraga, CAM; Lima, LM; Barreiro, EJ; Medeiros, IA. Cardiovascular effects induced by N-(4'-dihydro)-piperoylthiomorpholine in normotensive rats. Journal of Pharmacy and Pharmacology, 62, 1794-1800, 2010.

• Coasta DG; Silva JS; Kummerle, AE; Sudo, RT; Landgraf SL; Caruso-Neves, C; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, Gisele. LASSBio-294. A compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves ca2+ influx sarcoplasmic reticulum after myocardial infarction into. American Journal of Hypertension, 23, 1220-1227, 2010.

• Regasini, LO; Pivatto, M; Scorzoni, L; Benaducci, T; Fusco-Almeida, AM; Giannini, MJSM; Barreiro, EJ; Siva, DHS; Bolzani, VS. Antimicrobial activity of Pterogyne nitens Tul, Fabaceae, against opportunistic fungi. Revista Brasileira de Farmacognosia (Impresso), 20, 706-711, 2010.

• Lessa, JA; Mendes, IC; da Silva, PRO; Soares, MA; dos Santos, RG; Speziali, NL; Romeiro, NC; Barreiro, EJ; Beraldo, H. 2-Acetylpyridine thiosemicarbazones: Cytotoxic activity in nanomolar doses against malignant gliomas. European Journal of Medicinal Chemistry, 45, 5671-5677, 2010.

• Barreiro, EJ; Menegatti, R; Neves, G; Kliemann, M; Betti, AH; Rates, SMK; Leandro, T; Conrado, DJ; Costa, TDalla; Oliveira, V; Noel, F. Descoberta de novos protótipos N-fenilpiperazínicos heteroarilazólicos candidatos a fármacos antipsicóticos atípicos. Revista Virtual de Química, 02, 28-37, 2010.

• Barreiro, EJ; Viegas Junior, C; Cavalheiro, AJ; Bolzani, VS; Pivatto, Marcos; Young, MCM; Castro, NG; Rocha, MS; Fraga, CAM. Espectalina, cassina e análogos semissintéticos como potenciais candidatos a fármacos para o tratamento da doença de Alzheimer. Revista Virtual de Química, 2, 38-2010, 2010.

• Barreiro, EJ; Rocco, PRM; Xisto, DG; Silva JD; Diniz MFFM; Almeida, RN; Luciano, M N; Medeiros, IA; Cavalcanti, Bruno C; Ferreira, JRO; Moraes, MO; Costa-Lotufo, L V; Pessoa CO; Cattani, VB; Lima, LM. LASSBio - 596: da descoberta aos ensaios pré - clínicos. Revista Virtual de Química, 02, 10-27, 2010.

Floriano Paes Silva Junior

• Ferreira, SB; Sodero, ACR; Cardoso, MFC; Lima, ES; Kaiser, CR; Silva, FP; Ferreira, VF. Synthesis, biological activity, and molecular modeling studies of 1 h -1,2,3-triazole derivatives of carbohydrates as α-glucosidases inhibitors. Journal of Medicinal Chemistry, 53, 2364-2375, 2010.

• Romero, L; Marcussi, S; Marchi-Salvador, DP; Silva Jr, FP; Fuly, AL; Stábeli, RG; Silva, SL; González, J; Monte, A; Soares, AM. Enzymatic and structural characterization of a basic phospholipase A2 from the sea anemone Condylactis gigantea. Biochimie (Paris. Print), 92, 1063-1071, 2010.

François Germain Noel

• Pimenta, PHC; Silva, CLM; Noël, F. Ivermectin is a nonselective inhibitor of mammalian P-type ATPases. Naunyn-Schmiedeberg's Archives of Pharmacology, 381, 147-152, 2010.

• Schaffazick, N; Amaral, LS; Fonseca, TF; Tomaz, MA; Gaban, GA; Borges, PA; Calil-Elias, S; Noël, F; Melo, PA; Quintas, LEM. Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection. Toxicon (Oxford), 55, 52-60, 2010.

• Julião, LS; Leitão, SG; Lotti, C; Picinelli, AL; Rastrelli, L; Fernandes, PD; Noël, F; Thibaut, JPB ;Leitão, GG. Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. Phytochemistry, 71, 294-300, 2010.

• Barreto, F; Rezende, DC; Scaramello, CBV; Silva, CLM; Cunha, VMN; Caricati-Neto, A; Jurkiewicz, A; Noël, F; Quintas, LEM. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors. Brazilian Journal of Medical and Biological Research (Impresso), 43, 500-505, 2010.

• Neves, G; Menegatti, R; Antonio, CB; Grazziottin, LR; Vieira, RO; Rates, SMK; Noël, F; Barreiro, EJ; Fraga, CAM. Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorganic & Medicinal Chemistry, 18, 1925-1935, 2010.

• Pazini, F; Menegatti, R; Sabino, JR; Andrade, CH; Neves, G; Rates, SMK; Noël, F; Fraga, CAM; Barreiro, EJ; Oliveira, V. Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. Bioorganic & Medicinal Chemistry Letters, 20, 2888-2891, 2010.

• Fraga, CAM; Menegatti, R; Barreiro, EJ; Betti AH; Neves, G; Kliemann, M; Rates, SMK; Tasso, L; Conrado DJ; Costa, TD; Oliveira, V; Noël, F. Descoberta de novos protótipos N-fenilpiperazínicos heteroarilazólicos candidatos a fármacos antipsicóticos atípicos. Revista Virtual de Química, 2, 28-37, 2010.

Gilda Angela Neves

• Fraga, CAM; Menegatti, R; Barreiro, EJ; Neves, G; Betti, AH; Kliemann, M; Rates, S MK; Tasso, L; Conrado, DJ; Dalla Costa, T; Oliveira, V; Noel, FG. Descoberta de novos protótipos N-fenilpiperazínicos heteroarilazóicos candidatos a fármacos antipsicóticos atípicos. Revista Virtual de Química, 2, 28-37, 2010.

• Neves, G; Menegatti, R; Antonio, CB; Grazziotin, LR; Vieira, RO; Rates, SMK; Noel, FG; Barreiro, EJ; Fraga, CAM. Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors. Bioorganic & Medicinal Chemistry (Print), 18, 1925-1935, 2010.

• Pazini, F; Menegatti, R; Sabino, JR; Andrade, CH; Neves, G; Rates, SMK; Noel, FG; Fraga, CAM; Barreiro, EJ; Oliveira, V. Design of new dopamine D2 receptor ligands: Biosynthesis and pharmacological evaluation of the hydroxylated metabolite of LASSBio-581. Bioorganic & Medicinal Chemistry Letters (Print), 20, 2888-2891, 2010.

Gisele Zapata Sudo

• Sudo, RT; Calasans-Maia, JA; Zapata-Sudo, G; Galdino, SL; Pitta, IR. Interaction of morphine with a new alpha2-adrenoceptor agonist in mice. Journal of Pain, 11, 71-78, 2010.

• Nascimento-Junior, NM; Mendes, TCF; Leal, DM; Correa, CMN; Sudo, RT; Zapata-Sudo, G; Sant'Anna, CMR; Barreiro, EJ; Fraga, CAM. Microwave-assisted synthesis and pharmacological evaluation of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives in sedation model. Bioorganic & Medicinal Chemistry, 20, 74-77, 2010.

• Correa, CMN; Sudo, GZ; Sudo, RT. Efeitos Hemodinâmicos do Atracurio e Cisatracurio e o Uso de Difenidramina e Cimetidina. Revista Brasileira de Anestesiologia (Impresso), 60, 52-63, 2010.

• Queiroz-Madeira, EP; Lara, LS; Wengert, M; Landgraf, SS; Líbano-Soares, JD; Zapata-Sudo, G; Sudo, RT; Takiya, CM; Gomes-Quintana, E ; Lopes, AG . Na+-ATPase in spontaneous hypertensive rats: Possible AT1 receptor target in the development of hypertension. Biochimica et Biophysica Acta. Biomembranes, 1798, 360-366, 2010.

• Zapata-Sudo, G; Mendes, TCF ; Kartnaller, MA; Fortes, TO; Freitas, NFB; Kaplan, MAC; Sudo, RT. Sedative and anticonvulsant activities of methanol extract of Dorstenia arifolia in mice. Journal of Ethnopharmacology, 20, 01-05, 2010.
  Sudo, RT ; Bonfá, L; Trachez, MM; Debom, R; Rizzi, MDR; Zapata-Sudo, G. Anesthetic profile of a non-lipid propofol microemulsion. Revista Brasileira de Anestesiologia (Impresso), 60, 475-483, 2010.

• Carmo, PLDO; Zapata-Sudo, G; Trachez, MM; Sudo, RT. Toxicological evaluation of azumolene after repeated intraperitoneal administration in rats. Fundamental & Clinical Pharmacology, 24, 491-500, 2010.

• Medei, E; Lima-Leopoldo, AP; Pereira JR, PP; Campos, D; Raimundo, JM; Sudo, RT; Zapata-Sudo, G; Bruder-Nascimento, T; Cordellini, S; Nascimento, JHM; Cicogna, AC. Could an unsaturated high-fat acid diet impair the cardiovascular system? Canadian Journal of Cardiology, 26, 542-548, 2010.

• Zapata-Sudo, G; Pereira, SL; Beiral, HJV; Kummerle, AE ; Raimundo, JM; Antunes, F ; Sudo, RT; Barreiro, EJ; Fraga, CAM. Pharmacological characterization of (3-thienylidene)-3,4-methylenedioxybenzoylhydrazide: a novel muscarinic agonist with antihypertensive profile. American Journal of Hypertension, 23, 135-141, 2010.

• Sudo, RT; Cunha, LB; Carmo, PL; Matos, AR; Trachez, MM; Cardoso, LA; Aguiar, MI; Abreu, AV; Zapata-Sudo, G. Use of caffeine-halothane contracture for malignant hyperthermia diagnosis in Brazil. Brazilian Journal of Medical and Biological Research (Impresso), 43, 549-556, 2010.

• Carmo, PL; Zapata-Sudo, G; Trachez, MM; Antunes, F; Guimarães, SEF; Debom, R; Rizzi, MDR; Sudo, RT. Intravenous administration of azumolene to reverse malignant hyperthermia in swine. Journal of Veterinary Internal Medicine, 24, 1224-1228, 2010.

• Gabriel, D; Silva, JS; Kummerle, AE; Sudo, RT; Landgraf, SS; Caruso-Neves, C; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G. LASSBio-294, a compound with inotropic and lusitropic activity, decreases cardiac remodeling and improves Ca2+ influx into sarcoplasmic reticulum after myocardial infarction. American Journal of Hypertension, 23, 1220-1227, 2010.

• Sudo, RT; Bonfá, L; Trachez, MM; Debom, R; Rizzi, MDR; Zapata-Sudo, G. Caracterização anestésica da nanoemulsão não lipídica de propofol. Revista Brasileira de Anestesiologia (Impresso), 60, 475-483, 2010.

Josiane Sabbadini Neves

• Neves, JS; Radke, Amy L; Weller, Peter F. Cysteinyl leukotrienes acting via granule membrane-expressed receptors elicit secretion from within cell-free human eosinophil granules. Journal of Allergy and Clinical Immunology, 125, 477-482, 2010.

Lidia Moreira Lima

• Santos, JL; Varanda, EA; Lima, LM; Chin, CM. Mutagenicity of new lead compounds to treat sickle cell disease symptoms in a salmonella/microsome assay. International Journal of Molecular Sciences (Online), 11, 779-788, 2010.

• Araújo Jr, JX; Julien, C; Barrès, C; Medeiros, IA; Ribeiro, EAN; Barreiro, EJ; Lima, LM. Cardiovascular Effects of a novel synthetic analogue of naturally occurring piperamides. Journal of Cardiovascular Pharmacology, 56, 293-299, 2010.

• Carvalho, GMC; Oliveira, VR; Soares, RM; Azevedo, SMFO; Lima, LM; Barreiro, EJ; Valença, SS; Saldiva, PHN; Faffe, DS ; Zin, WA. Can LASSBio 596 and dexamethasone treat acute lung and liver inflammation induced by microcystin-LR? Toxicon (Oxford), 56, 604-612, 2010.

• Silva, YKC; Augusto, CV; Barbosa, MLC; Melo, GMA; Queiroz, AC; Dias, TLMF; Bispo, B; Barreiro, EJ; Lima, LM; Alexandre-Moreira, MS. Synthesis and pharmacological evaluation of pyrazine N-acylhydrazone derivatives designed as novel analgesic and anti-inflammatory drug candidates. Bioorganic & Medicinal Chemistry (Print), 18, 5007-5015, 2010.

• Araújo-Júnior, JX; Ribeiro, EAN; Fraga, CAM; Lima, LM; Barreiro, EJ; Medeiros, IA. Cardiovascular effects induced by N-(4'-dihydro)-piperoylthiomorpholine in normotensive rats. Journal of Pharmacy and Pharmacology, 62, 1794-1800, 2010.

• Rocco, PRM; Xisto, DG; Diniz, MFM; Almeida, RN; Luciano, MN; Medeiros, IA; Cavalcante, BC; Ferreira, JRO; Moraes, MO; Costa-Lotufo, LV; Pessoa, CÓ;Dalla-Costa, T; Cattani, VB; Barreiro, EJ; Lima, LM. LASSBio-596: da descoberta aos ensaios pré-clínicos. Revista Virtual de Química, 2, 10-27, 2010.

Lucienne da Silva Lara Morcillo

• Queiroz-Madeira, EP; Lara, LS; Wengert, M; Landgraf SS; Líbano-Soares J; Zapata-Sudo G; Sudo, RT; Takya CM; Gomes-Quintana, E; Lopes, A G; Caruso-Neves, C. Na+-ATPase in spontaneous hypertensive rats: possible at1 receptor. Biochimica et Biophysica Acta. Biomembranes, 1798, 360-366, 2010.

• De Souza, AM; Carvalho, TLG; Lara, LS; Gomes-Quintana, E; Lopes, AG; Caruso-Neves, C. The stimulatory effect of angiotensin II on Na(+)-ATPase activity involves sequential activation of phospholipases and sustained PKC activity. Biochimica et Biophysica Acta. Biomembranes, 1798, 354-359, 2010.

• Lara, LS; Vives, D; Correa, JS; Cardozo, FP; Marques-Fernades, MF; Lopes, AG; Caruso-Neves, C. PKA-mediated effect of MAS receptor in counteracting angiotensin II-stimulated renal Na+-ATPase. Archives of Biochemistry and Biophysics (Print), 496, 117-122, 2010.

• Verdoorn, KS; Lindoso, RS; Lowe, J ; Lara, LS; Vieyra, A; Einicker-Lamas, M. Bone marrow mononuclear cells shift bioactive lipid pattern in injured kidney towards tissue repair in rats with unilateral ureteral obstruction. Nephrology, Dialysis, Transplantation (Print), 25, 3867-3874, 2010.

Luis Eduardo Menezes Quintas

• Schaffazick, N; Amaral, LS; Fonseca, TF; Tomaz, MA; Gaban, GA; Borges, PA; Calil-Elias, S; Noël, F; Melo, PA; Quintas, LEM. Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection. Toxicon (Oxford), 55, 52-60, 2010.

• Barreto, F; Rezende, DC; Scaramello, CBV; Silva, CLM; Cunha, VMN; Caricati-Neto, A; Jurkiewicz, A; Noël, F; Quintas, LEM. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active α1B-adrenoceptors. Brazilian Journal of Medical and Biological Research (Impresso), 43, 500-505, 2010.

• Quintas, LEM; Pierre, SV; Liu, L; Bai, Y; Liu, X; Xie, ZJ . Alterations of Na+/K+-ATPase function in caveolin-1 knockout cardiac fibroblasts. Journal of Molecular and Cellular Cardiolog, 49, 525-531, 2010.

Luzineide Wanderley Tinoco

• Merlino, A; Benitez, D; Chavez, S; Cunha, J; Hernández, P; Campillo, NE; Páez, JA; Cerecetto, H; González, M; Tinoco, LW. Development of second generation amidinohydrazones, thio- and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1,3-dioxide core scaffolds. MEDCHEMCOMM, 1, 216-228, 2010.

• Valente, LMM; Paixão, D; Nascimento, AC; Santos, PFP; Scheinvar, LA; Moura, MRL; Gomes, LNF; Silva, JFM; Tinoco, LW. Antiradical activity, nutritional potential and flavonoids of the cladodes of Opuntia monacantha (Cactaceae). Food Chemistry, 123, 1127-1131, 2010.

• Cunha, AG; Silva, AAT; Silva, AJR; Tinoco, LW; Almeida, RV; Alencastro, RB; Simas, ABC; Freire, DMG. Efficient kinetic resolution of (±)-1,2-O-isopropylidene-3,6-di-O-benzyl-myo-inositol with the lipase B of Candida antarctica. Tetrahedron: Asymmetry (Print), 21, 2899-2903, 2010.

Marco Aurélio Martins

• Silva, JP; Rodarte, RS; Calheiros, AS; Souza, CZ; Amendoeira, FC; Martins, MA; Silva, PMR; Frutuoso, VS; Barreto, E. Antinociceptive activity of aqueous extract of Bowdichia virgilioides in mice. Journal of Medicinal Food, 13, 348-351, 2010.

• Antunes, MA; Abreu, SC; Silva, AL; Parra-Cuentas, ER; Ab'Saber, AM; Capelozzi, VL; Ferreira, TPT; Martins, MA; Silva, PMR; Rocco, PRM. Sex-specific lung remodeling and inflammation changes in experimental allergic asthma. Journal of Applied Physiology (1985), 109, 855-863, 2010.

• Santos, RL; Farias, MLF; Mendonça, LMC; Gonçalves, RT; Martins, MA; Souza, MMG; Martins, MA. Effects of immunosuppressant FK-506 on tooth movement. Orthodontics & Craniofacial Research (Print), 13, 153-161, 2010.

• Martins, MA; Por que algumas pessoas têm alergia à picada de insetos? Ciencia Hoje das Criancas, 215, 12, 2010.

Marília Zaluar Passos Guimarães

• Nones, J; Spohr, TCLS; Furtado, DR; Sartore, RC; Paulsen, BS; Guimarães, MZP; Rehen, SK. Cannabinoids modulate cell survival in embryoid bodies. Cell Biology International, 34, 399-408, 2010.

• Tributino, JLM; Santos, MLH; Mesquita, CM; Lima, CKF; Silva, LL; Maia, RC; Duarte, CD; Barreiro, EJ; Fraga, CAM; Castro, NG; Miranda, ALP ; Guimaraes, MZP. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. British Journal of Pharmacology, 159, 1716-1723, 2010.

Newton Gonçalves de Castro

• Tributino, JLM; Santos, MLH; Mesquita, CM; Lima, CKF; Silva, LL; Maia, RC; Duarte, CM;Barreiro, EJ; Fraga, CAM; Castro, NG; Miranda, ALP; Guimaraes, MZP. LASSBio-881: an N-acylhydrazone transient receptor potential vanilloid subfamily type 1 antagonist orally effective against the hypernociception induced by capsaicin or partial sciatic ligation. British Journal of Pharmacology, 159, 1716-1723, 2010.

Nubia Boechat

• Boechat, N; Lages, AS; Kover, WB; Tiekink, ERT; Wardell, JL; Wardell, S. N -(4-Chlorophenyl)-1,1,1-trifluoro- N -(trifluoromethylsulfonyl)methanesulfonamide. Acta Crystallographica. Section E, 66, o506-o507, 2010.

• Boechat, N Lages, AS ; Kover, WB; Tiekink, ERT; Wardell, JL; Wardell, S. 2-chloro-6,6-dimethyl-5,6-dihydroindazolo[2,3-c]quinazoline. Acta Crystallographica. Section E, e66, 521-522, 2010.

• Boechat, N; Bastos, MM. Trifluoromethylation of carbonyl Compounds. Current Organic Synthesis, 7, 403-413, 2010.

• Boechat, N; Kover, WB; Ferreira, SB; Wardell, S; Wardell, JL; Tiekink, ERT. N-(4-Chlorophenyl) ethanimidamide. Acta Crystallographica. Section E, E 66, 958-967, 2010.

• Silva, CC; Pinheiro, MFT; Honorato, SB; Boechat, N; Ayala, AP. Triple Structural Transition below Room Temperature in the Antifilarial Drug Diethylcarbamazine Citrate. Crystal Growth & Design, 10, 3094-3101, 2010.

• Boechat, N; Ferreira, MLG; Bastos, MM; Camilo, ALS; Wardell, SMSV; Wardell, JL; Tiekink, ERT. Crystal and molecular structures of two triazole derivatives: 4-cyclopropyl-4,5-dihydro-1h-1,2,3-triazole and methyl 1-benzyl-1H-1,2,3-triazole-4-carboxylate. Journal of Chemical Crystallography, 40, 1137-1141, 2010.

Patricia Dias Fernandes

• Machado, DE; Berardo, PT; Landgraf, RGa; Fernandes, PD; Palmero, Celia; Alves, LMi; Abrão, MS; Nasciutti, LE. A selective cyclooxygenase-2 inhibitor suppresses the growth of endometriosis with an antiangiogenic effect in a rat model. Fertility and Sterility, 93, 2674-2679, 2010.

• Pinheiro, MMG; Bessa, SO; Fingolo, CE; Kuster, RM; Matheus, ME; Menezes, FS; Fernandes, PD. Antinociceptive activity of fractions from Couroupita guianensis Aubl. leaves. Journal of Ethnopharmacology, 127, 407-413, 2010.

• Julião, LS; Leitão, SG; Lotti, C; Picinelli, AL; Rastrelli, L; Fernandes, PD; Noël, F; Thibaut, JPB;Leitão, GG. Flavones and phenylpropanoids from a sedative extract of Lantana trifolia L. Phytochemistry, 71, 294-300, 2010.

• Gomes, NM; Rezende, CM; Fontes, SP; Matheus, ME; Pinto, AC; Fernandes, PD. Characterization of the antinociceptive and anti-inflammatory activities of fractions obtained from Copaifera multijuga Hayne. Journal of Ethnopharmacology, 128, 177-183, 2010.

• Oliveira, SI; Andrade, LNS; Onuchic, AC; Nonogaki, S; Fernandes, PD ; Pinheiro, MC; Rohde, CBS; Chammas, R; Jancar, S. Platelet-activating factor receptor (PAF-R)-dependent pathways control tumour growth and tumour response to chemotherapy. BMC Cancer (Online), 10, 200, 2010.

• Miranda, LSM; Marinho, BG; Costa, JS; Leitão, SG; Santos, TC; Monache, FD; Fernandes, PD; Vasconcellos, MLAA; Pereira, VLP. Structural determination Vitex cymosa Bertero active principle: Diastereoselective synthesis of (±)-trans-4-hydroxy-6-propyl-1-oxocyclohexan-2-one and its antinociceptive activity. Bioorganic Chemistry (Print), 38, 181-185, 2010.

Patrícia Machado Rodrigues e Silva Martins

• Silva, JP; Rodarte, RS; Calheiros, AS; Zanon, C; Amendoeira, FC; Martins, MA; Silva PMR; Frutuoso, VS; Barreto, EO. Antinociceptive activity of aqueous extract of Bowdichia virgilioides in mice. Journal of Medicinal Food, 13, 348-351, 2010.

• Queto, T; Xavier-Elsas, P; Gardel, MA; Luca, B; Barradas, M; Masid, D; Silva PMR; Peixoto CA; Vasconcelos, ZMF; Dias, EP; Gaspar-Elsas, MI. Inducible nitric oxide synthase/cd95l-dependent suppression of pulmonary and bone marrow eosinophilia by diethylcarbamazine. American Journal of Respiratory and Critical Care Medicine, 181, 429-437, 2010.

• Paiva, LA; Maya-Monteiro, C; Bandeira-Melo, C; Silva PMR; El-Cheikh, MC; Teodoro, A; Borojevic, R; Perez, SAC; Bozza, PT. Interplay of cysteinyl leukotrienes and TGF-beta in the activation of hepatic stellate cells from Schistosoma mansoni granulomas. Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids, 1801, 1341-1348, 2010.

• Antunes, M; Abreu, S; Silva, AL; Parra-Cuentras, ER; Absaber, AM; Capelozzi, VL; Ferreira, TPT; Martins, MA; Silva, PMR; Rocco, PR. Sex-specific lung remodeling and inflammation changes in experimental allergic asthma. Journal of Applied Physiology (1985), 109, 855-859, 2010.

Paulo de Assis Melo

• Melo, PA; Pinheiro, DA; Ricardo, HD; Fernandes, FFA; Tomaz, MA; El-kik, CZ; Strauch, MA; Fonseca, TF; Sifuentes, DN; Calil-Elias, S. Ability of a synthetic coumestan to antagonize Bothrops snake venom activities. Toxicon (Oxford), 55, 488-496, 2010.

• Schaffazick, N; Amaral, LS; Fonseca, TF; Tomaz, MA; Gaban, GA; Borges, PA; Calil-Elias, S; Noël, F; Melo, PA; Quintas, LEM. Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection. Toxicon (Oxford), 55, 52-60, 2010.

• Lourenço, AL; Carvalho, DP; Melo, PA; Silva, TSC. Gestão das inovações incrementais, o caso Omeprazola. Química Nova (Impresso), 33, 1000-1004, 2010.

• Oliveira, JT; Almeida, FM; Biancalana, A; Baptista, AF; Tomaz, MA; Melo, PA; Martinez, AMB. Mesenchymal stem cells into polycaprolactone conduit enhance median nerve regeneration, prevent dropping of creatine fosfokinase muscle levels and improve functional recovery in mice. Neuroscience, 170, 1295-1303, 2010.

Paulo Roberto Ribeiro Costa

• Souza, CC; Costa, PRR. A new and concise strategy to the enantioselective synthesis of (S)-2-amino-4-oxo-4-(pyridine-2-yl) butanoic acid from aspartic acid. Journal of the Brazilian Chemical Society (Impresso), 21, 777-781, 2010.

• Martin-Rodriguez, M; Nájera, C; Sansano, JM; Costa, PRR; de Lima, EC; Dias, AG . Binap-AgSbF6 vs. Binap-AgClO4 complexes as catalysts for the enantioselective 1,3-dipolar cycloaddition of azomethine ylides and alkenes. Synlett (Stuttgart), 2010, 962-966, 2010.

• Salustiano, EJS; Netto, CD; Fernandes, RF; Silva, AJM; Bacelar, TS; Castro, C P; Buarque, CD; Maia, RC; Costa, PRR. Comparision of the cytotoxic effect of lapachol, alfa-lapachone and 1,4-pentacyclicnaphthoquinones on leukemic cells. Investigational New Drugs, 28, 139-144, 2010.

• Melo PA; Pinheiro, DA; Ricardo, HD; Fernandes, FFA; Tomaz, MA; El-Kik, CZ; Strauch, MA; Fonseca, TF; Sifuentes, DN; Calil-Elias, S; Buarque, CD; Brito, FV; Costa, PRR; da Silva, AJM. Ability of a synthetic coumestan to antagonize Bothrops snake venom activities. Toxicon (Oxford), 55, 488-496, 2010.

• Buarque, CD; Pinho, VD; Vaz, BG; Eberlin, MN; Silva, AJM; Costa, PRR. Palladium-catalyzed oxyarylation of olefins using silver carbonate as the base. Probing the mechanism by electrospray ionization mass spectrometry. Journal of Organometallic Chemistry (Print), 695, 2062-2067, 2010.

• Netto, CD; Silva, AJM; Salustiano, EJS; Bacelar, TS; Riça, IG; Cavalcante, MC M; Rumjanek, VM; Costa, PRR. New pterocarpanquinones: Synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-α modulation in human PBMC cells. Bioorganic & Medicinal Chemistry (Print), 18, 1610-1616, 2010.

• Vaz, BG; Eberlin, MN; Silva, AJM; Costa, PRR. Palladium-catalyzed tandem heck-lactonization from o -iodophenols and enoates: synthesis of coumarins and the study of the mechanism by electrospray ionization mass spectrometry. Journal of Organic Chemistry, 75, 7085-7091, 2010.

Roberto Takashi Sudo

• Queiroz-Madeira, E; Lara, LL; Wengert, M; Landgraf, SS; Líbano-Soares, J; Zapata-Sudo, G; Sudo, RT; Takiya, CM; Gomes-Quintana, E; Lopes, AG; Caruso-Neves, C. Na+-ATPase in spontaneously hypertensive rats: possible AT1 receptor target in the development of hypertension. Biochimica et Biophysica Acta. Biomembranes, 1798, 360-366, 2010.

• Correa, CMN; Zapata-Sudo, G; Sudo, RT. Hemodynamic effects of atracurium and cisatracurium and the use of diphenhydramine and cimetidine. Revista Brasileira de Anestesiologia (Impresso), 60, 52-63, 2010.

• Nascimento-Junior, NM; Mendes, TCF; Leal, DM; Correa, CMN; Sudo, RT; Zapata-Sudo, G; Barreiro, EJ; Fraga, CAM. Microwave-assisted synthesis and pharmacological evaluation of neuroactive pyrazolo[3,4-b]pyrrolo[3,4-d]pyridine derivatives in sedation model. Bioorganic & Medicinal Chemistry Letters, 20, 74-77, 2010.

• Zapata-Sudo, G; Pereira, SL; Beiral, HJV; Kummerle, AE; Raimundo, JM; Barreiro, EJ; Sudo, RT; Fraga, CAM. Pharmacological characterization of (3-thienylidene)-3,4-methylenedioxybenzoylhydrazide, a novel muscarinic agonist with antihypertensive profile. American Journal of Hypertension, 23, 135-141, 2010.

• Sudo, RT; Calazans-Maia, JA; Galdino, SL; Lima, MCA; Zapata-Sudo, G; Hernandes, MZ; Pitta, IR. Interaction of morphine with a new alfa2-adrenoceptor agonist in mice. The Journal of Pain (Print), 11, 71-78, 2010.

• Carmo, PL; Zapata-Sudo, G; Trachez, MM; Antunes, F; Guimaraes, S; Debom, R; Sudo, RT. Intravenous administration of azumolene to reverse malignant hyperthermia in Swine. Journal of Veterinary Internal Medicine, 24, 1224-1228, 2010.

• Sudo, RT; Cunha LBP; Carmo, PL; Matos, AR; Trachez, MM; Cardoso, ALM; Aguiar, MIS; Abreu, AV; Zapata-Sudo, G. Use of the caffeine-halothane contracture for malignant hyperthermia diagnosis in Brazil. Brazilian Journal of Medical and Biological Research (Impresso), 43, 549-556, 2010.

• Zapata-Sudo, G; Mendes, TCF; Kartnaller MA; Fortes, TO; Freitas, NFB; Kaplan, MA C; Sudo, RT. Sedative and anticonvulsivant activity of methanol extract of Dorstenia arifolia in mice. Journal of Ethnopharmacology, 130, 9-12, 2010.

• Medei, E; Lima-Leopoldo, AP; Pereira Jr, PP; Campos, D; Raimundo, JM; Sudo, RT; Zapata-Sudo, G; Cicogna, AC. Could an unsaturated high-fat acid diet impair the cardiovascular system? Canadian Journal of Cardiology, 26, 542-548, 2010.

• Gabriel D; Silva, JS; Kummerle, AE; Sudo, RT; Landgraf, SS; Caruso-Neves, C; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G. LASSBio-294 a compound with inotropic and lusitropic activity decreases cardiac remodeling and improves Ca influx into SR after myocardial infarction. American Journal of Hypertension, 23, 1220-1227, 2010.

• Carmo, PL; Zapata-Sudo, G; Trachez, MM; Sales, MGF; Sudo, RT. Toxicological evaluation of azumolene after repeated intraperitoneal administration in rats. Fundamental & Clinical Pharmacology, 24, 491-500, 2010.

Valéria do Monti Nascimento Cunha

• Barreto, F; Rezende, DC; Scaramello, CBV; Silva, CLM; Cunha, VMN; Caricati Neto, A; Jurkiewicz, A; Noel, F; Quintas, LEM. Lack of evidence for regulation of cardiac P-type ATPases and MAP kinases in transgenic mice with cardiac-specific overexpression of constitutively active alpha(1B)-adrenoceptors. Brazilian Journal of Medical and Biological Research (Impresso), 43, 500-505, 2010.

• Schaffazick, N; Amaral, LS; Fonseca, TF; Tomaz, MA; Gaban, GA; Borges, PA; Calil-Elias, S; Noël, F; Melo, PA; Quintas, LEM; Cunha, VMN. Effect of heparin treatment on the expression and activity of different ion-motive P-type ATPase isoforms from mouse extensor digitorum longus muscle during degeneration and regeneration after Bothrops jararacussu venom injection. Toxicon (Oxford), 55, 52-60, 2010.

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