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Ana Luisa Palhares de Miranda

• Motta, NAV; Kümmerle, AE; Marostica, E; Santos, CF; Fraga, CAM; Barreiro, EJ; Miranda, ALP; Brito, FCF. Anti-atherogenic effects of a new thienylacylhydrazone derivative, lassbio-788, in rats fed a hypercholesterolemic diet. Journal of Pharmacological Sciences, 123, 47-57, 2013.

Carlos Alberto Manssour Fraga

• Gomes, TF; Pompeu, TET; Rodrigues, DA; Noel, F; Menegatti, R; Andrade, CH; Sabino, JR; Gil, ES; Dallacosta, T; Betti, AH; Antonio, CB; Rates, SMK; Fraga, CAM; Barreiro, EJ; Oliveira, V. Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. European Journal of Medicinal Chemistry, 62, 214-221, 2013.

• Neves, G; Antonio, CB; Betti, AH; Pranke, MA; Fraga, CAM; Barreiro, EJ; Noel, F; Rates, SMK. New insights into pharmacological profile of LASSBio-579, a multi-target N-phenylpiperazine derivative active on animal models of schizophrenia. Behavioural Brain Research, 237, 86-95, 2013.

• Pereira, SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Rocha, NN; Ferraz, EB; Nascimento, JHM; Sudo, RT; Zapata-Sudo, G . A novel Ca channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension. European Journal of Pharmacology, 702, 316-322, 2013.

• Silva, RB; Loback, VB; Salomão, K; Castro, SL; Wardell, JL; Wardell, SMSV; Costa, TEMM; Penido, C; Henriques, MGMO; Carvalho, SD; Silva, EF; Fraga, CAM. Synthesis and trypanocidal activity of novel 2,4,5-triaryl-n-hydroxylimidazole derivatives. Molecules (Basel. Online), 18, 3445-3457, 2013.

• Mendes, TCF; Antunes, F; Trachez, MM; Nascimento, NM; Fraga, CAM; Barreiro, EJ; Sudo, GZ; Sudo, RT. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clinical and Experimental Pharmacology & Physiology, 40, 404-411, 2013.

• Pompeu, TET; Alves, FRS; Figueiredo, CDM; Antonio, CB; Herzfeldt, V; Moura, BC; Rates, SMK; Barreiro, EJ; Fraga, CAM; Noël, F. Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. European Journal of Medicinal Chemistry, 66, 122-134, 2013.

• Silva, GAP; Kummerle, AE; Antunes, F; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G; Sudo, RT. Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice. Brazilian Journal of Medical and Biological Research on line, 46, 263-269, 2013.

• Alencar, AKN; Pereira, SL; Montagnoli, TL; Maia, RC; Kümmerle, AE; Landgraf, SS; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats. British Journal of Pharmacology, 169, 953-962, 2013.

• Motta, NAV; Kümmerle, AE; Marostica, E; Santos, CF; Fraga, CAM; Miranda, ALP; Brito, FCF. Anti-atherogenic effects of a new thienylacylhydrazone derivative, LASSBio-788, in rats fed a hypercholesterolemic diet. Journal of Pharmacological Sciences, 123, 47-57, 2013.

• Lopes, A; Miguez, E; Kümmerle, A; Rumjanek, V; Fraga, CAM; Barreiro, EJ. Characterization of amide bond conformers for a novel heterocyclic template of n-acylhydrazone derivatives. Molecules (Basel. Online), 18, 11683-11704, 2013.

Cláudia Lucia Martins da Silva

• El-Kik, CZ; Fernandes, FFA; Tomaz, MA; Gaban, GlA; Fonseca, TF; Calil-Elias, S; Oliveira, SDS; Silva, CLM; Martinez, AMB; Melo, PA. Neutralization of Apis mellifera bee venom activities by suramin. Toxicon (Oxford), 67, 55-62, 2013.

• Guethe, LM; Pelegrini-da-Silva, A; Borelli, KG; Juliano, MA; Pelosi, GG; Pesquero, JB; Silva, CLM; Corrêa, FMA; Murad, F; Prado, WA; Martins, AR . Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience, 231, 315-327, 2013.

• Oliveira, S; Coutinho-Silva, R; Silva, CLM. Endothelial P2X7 receptors expression is reduced by schistosomiasis. Purinergic Signalling (Print), 9, 81-89, 2013.

Didier Jean Jacques Salmon

• Brasseur, A; Rotureau, B; Vermeersch, M; Blisnick, T; Salmon, D; Bastin, P; Pays, E; Vanhamme, L; Perez-Morga, D. Trypanosoma brucei FKBP12 differentially controls motility and cytokinesis in procyclic and bloodstream forms. Eukaryotic Cell (Online), 12, 168-181, 2013.

• Aido-Machado, R; Salmon, D; Pires, JR. 1H, 15N and 13C assignments of a putative peptidyl prolyl cis trans isomerase FKBP12 from Trypanosoma brucei. Biomolecular NMR Assignments (Print), 1, ehead of print, 2013.

Eliezer Jesus de Lacerda Barreiro

• Alencar, AKN; Pereira, SL; Montagnoli, TL; Maia, RC; Kümmerle, AE; Landgraf, SS; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats. British Journal of Pharmacology, 169, 953-962, 2013.

• Pereira, SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Rocha, NN; Ferraz, EB; Nascimento, JHM; Sudo, RT; Zapata-Sudo, G . A novel Ca channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension. European Journal of Pharmacology, 702, 316-322, 2013.

• Mendes, TCF; Antunes, F; Trachez, MM; Nascimento, NM; Fraga, CAM; Barreiro, EJ; Sudo, GZ; Sudo, RT. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clinical and Experimental Pharmacology & Physiology, 40, 404-411, 2013.

• Hernández, P; Rojas, R; Gilman, RH; Sauvain, M; Lima, LM; Barreiro, EJ; González, M; Cerecetto, H. Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates. European Journal of Medicinal Chemistry, 59, 64-74, 2013.

• Costa, FN; Braz, D; Ferreira, FF; Silva, TF; Barreiro, EJ; Lima, LM; Colaço, MV; Kuplich, L; Barroso, RC. Synchrotron X-ray powder diffraction data of LASSBio-1515: A new N-acylhydrazone derivative compound. Radiation Physics and Chemistry (1993), 89, 1-5, 2013.

• Ferreira, EI; Barreiro, EJ; Andrade, CH. XII National Meeting of Pharmaceutical Chemistry Professors: could we have now a subarea of Pharmaceutical and Medicinal Chemistry in the CNPq Pharmacy Comittee? Brazilian Journal of Pharmaceutical Sciences (Impresso), 49, v-vi, 2013.

• Silva, GAP; Kummerle, AE; Antunes, F; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G; Sudo, RT. Impairment of locomotor activity induced by the novel N-acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice. Brazilian Journal of Medical and Biological Research on line, 46, 263-269, 2013.

• Gomes, TF; Pompeu, TET; Rodrigues, DA; Noël, F; Menegatti, R; Andrade, CH; Sabino, JR; Gil, ES; Costa, TD; Betti, AH; Antonio, CB; Rates, SMK; Fraga, CAM; Barreiro, EJ; Oliveira, V. Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. European Journal of Medicinal Chemistry, 62, 214-221, 2013.

• Pompeu, TET; Alves, FRS; Figueiredo, CDM; Antonio, CB; Antonio, CB; Herzfeldt, V; Moura, BC; Barreiro, EJ; Rates, SMK; Fraga, CAM; Noël, F. Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. European Journal of Medicinal Chemistry, 66, 122-134, 2013.

• Motta, NAV; Kümmerle, AE; Marostica, E; Santos, CF; Fraga, CAM; Barreiro, EJ; Miranda, ALP; Brito, FCF. Anti-atherogenic effects of a new thienylacylhydrazone derivative, LASSBio-788, in rats fed a hypercholesterolemic diet. Journal of Pharmacological Sciences, 123, 47-57, 2013.

• Frattani, FS; Coriolano, EO; Lima, LM; Zingali, RB; Barreiro, EJ. Oral antithrombotic effects of acylhydrazone derivatives. Journal of Atherosclerosis and Thrombosis, 20, 287-295, 2013.

• Pinto, AC; Barreiro, EJ. Desafios da indústria farmacêutica brasileira. Química Nova (Impresso), 36, 1557-1560, 2013.

• Lopes, A; Miguez, E; Kümmerle, AE; Rumjanek, V; Fraga, CAM; Barreiro, EJ. Characterization of amide bond conformers for a novel heterocyclic template of n-acylhydrazone derivatives. Molecules (Basel. Online), 18, 11683-11704, 2013.

• Costa, FN; Ferreira, FF; Silva, TF; Barreiro, EJ; Lima, LM; Braz, D; Barroso, RC. Structure re-determination of LASSBio-294 - a cardioactive compound of the N-acylhydrazone class - using X-ray powder diffraction data. Powder Diffraction, 28, S491-S509, 2013.

• Barreiro, EJ. As Longas Pernas do Laboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®;http://www.farmacia.ufrj.br/lassbio): Histórico e Perspectivas. Revista Virtual de Química, 5, 266-282, 2013.

• Barreiro, EJ; Pinto, AC. Opportunities and Challenges for Innovation in Pharmaceuticals: Now or Never. Revista Virtual de Química, 5, 1059-1074, 2013.

• Amaral, DN; Barreiro, EJ; Lima, LM. Thionyl chloride (CAS No 7719-09-7) - Método de preparação industrial de solventes e reagentes químicos. Revista Virtual de Química, 05, 1204-1208, 2013.

• Benítez, J; Queiroz, AC; Correia, I; Alves, MA; Alexandre-Moreira, MS; Barreiro, EJ; Lima, LM; Varela, J; González, M; Cerecetto, H; Moreno, V; Pessoa, JC; Gambino, D. New oxidovanadium(IV) N-acylhydrazone complexes: Promising antileishmanial and antitrypanosomal agents. European Journal of Medicinal Chemistry, 62, 20-27, 2013.

Fabio de Sousa Menezes Boylan

• Sousa, VP; Crean, J; Borges, VRA; Rodrigues, CR; Tajber, L; Boylan, F, Cabral, LM. Nanostructured systems containing babassu (Orbignya speciosa) oil as a potential alternative therapy for benign prostatic hyperplasia. International Journal of Nanomedicine, 8, 3129-3139, 2013.

• Pinheiro, MMG; Fernandes, SB; Fingolo, CE; Boylan, F; Fernandes, PD. Anti-inflammatory activity of ethanol extract and fractions from Couroupita guianensis Aublet leaves. Journal of Ethnopharmacology, 146, 324-330, 2013.

• Radulovic, NS; Miltojevic, AB; Randjelovic, PJ; Stojanovic, NM; Boylan, F. Effects of methyl and isopropyl N-methylanthranilates from Choisya ternata Kunth (Rutaceae) on experimental anxiety and depression in mice. Phytotherapy Research, 27, 1334-1338, 2013.

Floriano Paes Silva Junior

• Neves, AP; Pereira, MXG; Peterson, EJ; Kipping, R; Vargas, MD; Silva-Jr, FP; Carneiro, JM; Farrell, NP. Exploring the DNA binding/cleavage, cellular accumulation and topoisomerase inhibition of 2-hydroxy-3-(aminomethyl)-1,4-naphthoquinone Mannich bases and their platinum(II) complexes. Journal of Inorganic Biochemistry, 119, 54-64, 2013.

• Silveira, LB; Marchi-Salvador, DP; Santos-Filho, NA; Silva, FP; Marcussi, S; Fuly, AL; Nomizo, A; Silva, SL; Stábeli, RG; Arantes, ElC; Soares, AM. Isolation and expression of a hypotensive and anti-platelet acidic phospholipase A2 from Bothrops moojeni snake venom. Journal of Pharmaceutical and Biomedical Analysis (Print), 73, 35-43, 2013.

• Oliveira, RB; Senger, MR; Vasques, LM; Gasparotto, J; Santos, JPA; Pasquali, MAB; Moreira, JCF; Silva, FP; Gelain, DP. Schistosoma mansoni infection causes oxidative stress and alters receptor for advanced glycation endproduct (RAGE) and tau levels in multiple organs in mice. International Journal for Parasitology, 43, 371-379, 2013.

• Farias, LP; Krautz-Peterson, G; Tararam, CA; Montoya, BOA; Fraga, TR; Rofatto, HK; Silva-JR, FP; Isaac, L; Wilson, A; Shoemaker, CB; Leite, LCC. On the three-finger protein domain fold and CD59-like proteins in schistosoma mansoni. PLoS Neglected Tropical Diseases (Online), 7, e2482, 2013.

François Germain Noel

• Rezende, DC; Poças, ES; Muzi-Filho, H; Cunha, VMN; Caricati-Neto, A; Jurkiewicz, A; Noël, F; Quintas, LEM. Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice. Journal of Physiology and Biochemistry, 69, 207-214, 2013.

• Gomes, TF; Pompeu, TET; Rodrigues, DA; Noël, F; Menegatti, R; Andrade, H; Sabino, JR; Gil, ES; Costa, TD; Betti, AH; Antonio, CB; Rates, SMK ; Fraga, CAM; Barreiro, EJ; Oliveira, V. Biotransformation of LASSBio-579 and pharmacological evaluation of p-hydroxylated metabolite a N-phenylpiperazine antipsychotic lead compound. European Journal of Medicinal Chemistry, 62, 214-221, 2013.

• Rodriguez, JBR; Muzi-Filho, H; Valverde, R; Quintas, LEM; Noël, F; Lamas, ME; Cunha, VMN . SERCA2 is present in the rat vas deferens and is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation. Brazilian Journal of Medical and Biological Research (Impresso), 46, 227-234, 2013.

• Pompeu, TET; Alves, FR; Figueiredo, CD; Antonio, CB; Herzfeldt, V; Rates, SMK; Barreiro, EJ; Fraga, CAM; Noël, F. Synthesis and pharmacological evaluation of new N-phenylpiperazine derivatives designed as homologues of the antipsychotic lead compound LASSBio-579. European Journal of Medicinal Chemistry, 66, 122-134, 2013.

Gilda Angela Neves

• Neves, G; Antonio, CB; Betti, AH; Pranke, MA; Fraga, CAM; Barreiro, EJ; Noël, FG; Rates, SMK. New insights into pharmacological profile of LASSBio-579, a multi-target n-phenylpiperazine derivative active on animal models of schizophrenia. Behavioural Brain Research, 237, 86-95, 2013.

Gisele Zapata Sudo

• Silva, GAP; Kummerle, AE; Antunes, F; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G ; Sudo, RT. Locomotor activity Impairment in mice induced by novel n-acylhydrazone derivatives LASSBio-785 and LASSBio-786. Brazilian Journal of Medical and Biological Research (Impresso), 46, 263-269, 2013.

• Pereira, SL; Marques, A; Sudo, RT ; Kaplan, MA; Zapata-Sudo, G . Vasodilator activity of the essential oil from aerial parts of Pectis brevipedunculata and its main constituent citral in rat aorta. Molecules (Basel. Online), 18, 3072-3085, 2013.

• Pereira, SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Rocha, NN; EB; Nascimento, JHM; Sudo, RT; Zapata-Sudo, G. A novel Ca+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension. European Journal of Pharmacology, 702, 316-322, 2013.

• Mendes, TCF; Antunes, F; Trachez, MM; Nascimento, NM; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G; Sudo, RT. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clinical and Experimental Pharmacology & Physiology, 40, 404-411, 2013.

• Alencar, AKN; Pereira, SL; Montagnoli, TL; Maia, RC; Kümmerle, AE; Landgraf, SS; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Sant'anna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Beneficial effects of a novel agonist of the adenosine A _2A receptor on monocrotaline-induced pulmonary hypertension in rats. British Journal of Pharmacology, 169, 953-962, 2013.

• Alencar, AKN; Pereira, SL; Cunha, VMN; Lima, LM; Tesch, R; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. A novel adenosine A2A receptor agonist attenuates the progression of monocrotaline-induced pulmonary hypertension in rats. Journal of Pulmonary & Respiratory Medicine, S4, 1-6, 2013.

Josiane Sabbadini Neves

• Muniz, V; Baptista-dos-Reis, R; Josiane S Neves. Functional Extracellular Eosinophil Granules: A Bomb Caught in a Trap. International Archives of Allergy and Immunology (Online), 162, 276-282, 2013.

• Guilherme, RF; Xisto, DG; Kunkel, SL; Freire-de-Lima, CG; Rocco, PRM; Neves, JS; Fierro, IM; Canetti, C; Benjamim, CF. Pulmonary Antifibrotic Mechanisms Aspirin-Triggered Lipoxin A ₄ Synthetic Analog. American Journal of Respiratory Cell and Molecular Biology, 49, 1029-1037, 2013.

Lidia Moreira Lima

• Hernández, P; Rojas, R; Gilman, RH; Sauvain, M; Lima, LM; Barreiro, EJ; González, M; Cerecetto, H. Hybrid furoxanyl N-acylhydrazone derivatives as hits for the development of neglected diseases drug candidates. European Journal of Medicinal Chemistry, 59, 64-74, 2013.

• Benítez, J; Queiroz, AC; Correia, I; Alves, MA; Alexandre-Moreira, MS; Barreiro, EJ; Lima, LM; Varela, J; González, M; Cerecetto, H; Moreno, V; Pessoa, JC; Gambino, D. New oxidovanadium(IV) N-acylhydrazone complexes: Promising antileishmanial and antitrypanosomal agents. European Journal of Medicinal Chemistry, 62, 20-27, 2013.

• Frattani, FL; Serra, CA; Oliveira, E; Lima, LM; Barreiro, EJ; Zingali, RB. Oral antithrombotic effects of acylhydrazone derivatives. Journal of Atherosclerosis and Thrombosis, 20, 287-295, 2013.

• Costa, FN; Ferreira, FFurlan; Silva, TF; Barreiro, EJ; Lima, LM; Braz, D; Barroso, RC. Structure re-determination of LASSBio-294 - a cardioactive compound of the N-acylhydrazone class - using X-ray powder diffraction data. Powder Diffraction, 28, S491-S509, 2013.

• Lima, LM; Amaral, DN. Beirut reaction and its application in the synthesis of quinoxaline-dioxides bioactive compounds. Revista Virtual de Química, 5, 1075-1100, 2013.

Lucienne da Silva Lara Morcillo

• Muzi-Filho H; Bezerra, CGP; Souza, AM; Boldrini LC; Melo, MC; Oliveira, FL; Nesi, RT; Valenca, SS; Einicker-Lamas, M; Vieyra, A; Lara, LS; Cunha, VMN. Undernutrition affects cell survival, oxidative stress, Ca2+ handling and signaling pathways in vas deferens, crippling reproductive capacity. Plos One, 8, e69682-e69682, 2013.

Luis Eduardo Menezes Quintas

• Quintas, LEM; Rodriguez, JBR; Muzi-Filho, H; Valverde, RH; Einicker, M; Cunha, VMN. Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation. Brazilian Journal of Medical and Biological Research on line, 46, 227-234, 2013.

• Rezende, DC; Pôças, ESC; Muzi-Filho, H; Cunha, VMN; Caricati-Neto, A; Jurkiewicz, A; Noël, F; Quintas, LEM. Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice. Journal of Physiology and Biochemistry, 69, 207-214, 2013.

Marco Aurélio Martins

• Insuela, DBR; Silva, PMR; Martins, MA; Carvalho, VF. The yin yang of hormones that control glucose homeostasis in asthma. Journal of Allergy & Therapy, S11, 1-8, 2013.

• Vieira, AB; Coelho, LP; Santos, MH; Insuela, DBR; Carvalho, VF; Silva, PMR; Martins, MA. Mangiferin prevents guinea pig tracheal contraction via activation of the nitric oxide-cyclic gmp pathway. Plos One, 8, e71759, 2013.

• Bargut, TCL; Ferreira, TPT; Daleprane, JB; Martins, MA; Silva, PMR; Aguila, MB. Fish oil has beneficial effects on allergen-induced airway inflammation and hyperreactivity in mice. Plos One, 8, e75059, 2013.

• Ribeiro-Filho, J; Calheiros, AS; Vieira-de-Abreu, A; Carvalho, KIM; Mendes, DS; Melo, CB; Martins, MA; Dias, Silva; MRPC; Bozza, PT. Curine inhibits eosinophil activation and airway hyper-responsiveness in a mouse model of allergic asthma. Toxicology and Applied Pharmacology, 00, 000-000, 2013.

• Torres, RC; Prevatto, J; Silva, PMR; Martins, MA; Carvalho, V. From type-1 diabetes HPA axis to the disease complications. Journal of Diabetes & Metabolism, S12, 002, 2013.

• Ferreira, TPT; Arantes, ACS; Nascimento, CVMF; Olsen, PC; Trentin, PG; Rocco, PRM; Hogaboam, CM; Puri, RK; Martins, MA; Silva, PMRE. IL-13 Immunotoxin accelerates resolution of lung pathological changes triggered by silica particles in mice. The Journal of Immunology (1950), 191, 5220-5229, 2013.

Marília Zaluar Passos Guimarães

• Perdigão, PS; Serrano, MAR; Flausino Jr, O; Bolzani, VS; Guimarães, MZP; Castro, NG. Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. Plos One, 8, e82726, 2013.

Newton Gonçalves de Castro

• Perdigão, PS; Serrano, MAR; Flausino Jr, O; Bolzani, VS; Guimarães, MZP; Castro, NG. Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells. Plos One, 8, e82726, 2013.

Nubia Boechat

• Ferrreira, VF; Rocha, D; Silva, F; Ferreira, P; Boechat, N; Magalhães JL. Novel 1 -1,2,3-, 2 -1,2,3-, 1 -1,2,4- and 4 -1,2,4-triazole derivatives: a patent review (2008 2011). Expert Opinion on Therapeutic Patents, 23, 319-331, 2013.

• Boechat, N; Bastos, MM; Duarte, SL; Costa, J; Mafra, JCM; Daniel, LCC. Mesilato de Imatinibe: Uma Otimização em sua Síntese. Revista Virtual de Química, 5, 222-234, 2013.

• Bastos, MM; Gomes, ATPC; Neves, MGPMS; Silva, AMS; Santos-Filho, OA; Boechat, N; Cavaleiro, JAS. Synthesis of β-substituted porphyrin derivatives containing heterocyclic moieties as potential photosensitizers against cutaneous leishmaniasis. European Journal of Organic Chemistry (Print), 2013, 1485-1493, 2013.

• Boechat, N; Bastos, MM. Fluorinated compounds against Mycobacterium tuberculosis. Current Topics in Medicinal Chemistry (Print), 13, 2885-2904, 2013.

• Branco, FSC; Pinto, AC; Boechat, N. An update on the chemistry and medicinal chemistry of novel antimycobacterial compounds. Current Topics in Medicinal Chemistry (Print), 13, 2808-2849, 2013.

• Magalhães JL; Quoniam, L; Boechat, N; Kenap, AA. Neglected disease in social network? A blueprint of Dengue in twitter as a contribution of information science for public healt. International Journal of Management, IT and Engineering, 3, 194-204, 2013.

• Boechat, N; Magalhães JL; Quoniam, L. Web 2.0 Tools for Network Management and Patent Analysis for Health Public.. Revista Eletrônica Gestão & Saúde, 02, 26-41, 2013.

• Boechat, N; Magalhães JL; Quoniam, L; Ferreira, VF; Ferreira, P. Research on pharmaceuticals patents in times of Big data: a contribution of the Web 2.0 for medicinal chemistry. Intellectual Properties Rights: Open Access, 13, 01-09, 2013.

• Mello, FVC; Carvalho, AS; Bastos, MM; Boechat, N; Aiub, CAF; Felzenszwalb, I. Evaluation of genotoxic effects of new molecules with possible trypanocidal activity for chagas disease treatment. The Scientific World Journal, 2013, 1-8, 2013.

• Boechat, N; Lages, AS; Bastos, MM; Genestra, MS; Santos-Filho, OA; Kover, WB. Synthesis of simple molecules prepared as arginase inhibitors and evaluated against Leishmania amazonensis. Journal of Microbiology and Antimicrobials, 05, 72-86, 2013.

Patricia Dias Fernandes

• Figueiredo, GSM; Zardo, RS; Silva, BV; Violante, F; Pinto, AC; Fernandes, PD. Convolutamydine A and synthetic analogues have antinociceptive properties in mice. Pharmacology, Biochemistry and Behavior, 103, 431-439, 2013.

• Peçanha, LMT; Fernandes, PD; Simen, TJM; Oliveira, DR; Finotelli, PV; Pereira, MVA; Barboza, FF; Almeida, TS; Carvalhal, S; Pierucci, APTR; Leitão, GG; Rastrelli, L; Piccinelli, AL; Leitão, SG. Immunobiologic and anti-inflammatory properties of a bark extract from Ampelozizyphus amazonicus Ducke. BioMed Research International, 2013, 1-11, 2013.

• Silva, RR; Silva, DO; Fontes, HR; Alviano, CS; Fernandes, PD; Alviano, DS. Anti-inflammatory, antioxidant, and antimicrobial activities of Cocos nucifera var. typica. BMC Complementary and Alternative Medicine (Online), 13, 107-114, 2013.

• Pinheiro, MMG; Fernandes, SBO; Fingolo, CE; Boylan, F; Fernandes, PD. Anti-inflammatory activity of ethanol extract and fractions from Couroupita guianensis Aublet leaves. Journal of Ethnopharmacology, 146, 324-330, 2013.

Patrícia Machado Rodrigues e Silva Martins

• Insuella, DB; Silva PMR; Martins, MA; Carvalho, V. the yin yang of hormones that control glucose homeostasis in asthma. Journal of Allergy and Therapy, S11, 1-8, 2013.

• Lepletier, A; Carvalho, VF; Silva PMR; Villar, S; Perez, AR; Savino, W; Morrot, A. Trypanosoma cruzi disrupts thymic homeostasis by altering intrathymic and systemic stress-related endocrine circuitries. PLoS Neglected Tropical Diseases (Online), x, xxx, 2013.

• Bargut, TCL; Ferreira, TPT; Daleprane, JB; Martins, MA; Silva PMR; Aguila, MB. Fish oil has beneficial effects on allergen-induced airway inflammation and hyperreactivity in mice. Plos One, 8, e75059, 2013.

• Torres, RC; Prevatto, J; Silva PMR; Martins, MA; Carvalho, V. From type-1 diabetes HPA axis to the disease complications. Journal of Diabetes & Metabolism, S12, 002, 2013.

• Ferreira, TPT; Arantes, ACS; Nascimento, CVMF; Olsen, PC; Trentin, PG; Rocco, PRM; Hogaboam, CM; Puri, R; Martins, MA; Silva, PMR. IL-13 Immunotoxin accelerates resolution of lung pathological changes triggered by silica particles in mice. The Journal of Immunology (1950), 5220-5229, 2013.

Paulo de Assis Melo

• Patrão-Neto, FC; Tomaz, MA; Strauch, MA; Monteiro-Machado, M; Rocha-Junior, JR; Melo, PA. Dexamethasone antagonizes the in vivo myotoxic and inflammatory effects of Bothrops venoms. Toxicon (Oxford), 01-10, 2013.

• El-Kik, CZ; Fernandes, FFA; Tomaz, MA; Gaban, GA; Fonseca, TF; Calil-Elias, S; Oliveira, SD; Silva, CLM; Martinez, AMB; Melo, PA. Neutralization of Apis mellifera Bee venom activities by suramin. Toxicon (Oxford), 55-62, 2013.

• Lopes, FRP; Martin, PKM; Frattini, F; Biancalana, A; Almeida, FM; Tomaz, MA; Melo, PA; Borojevic, R; Han, SW; Martinez, AMB. Double gene therapy with granulocyte colony-stimulating factor and vascular endothelial growth factor acts synergistically to improve nerve regeneration and functional outcome after sciatic nerve injury in mice. Neuroscience, 230, 184-197, 2013.

• Strauch, MA; Tomaz, MA; Monteiro-Machado, M; Ricardo, HD; Ricardo, HD; Cons, BL; Fernandes, FFA; El-Kik, CCZ; Azevedo, MS; Melo, PA . Antiophidic activity of the extract of the Amazon plant Humirianthera ampla and constituents. Journal of Ethnopharmacology, 145, 50-58, 2013.

Paulo Roberto Ribeiro Costa

• Bacelar, TS; Silva, AJM; Costa, PRR; Rumjanek, VM. The pterocarpanquinone LQB 118 induces apoptosis in tumor cells through the intrinsic pathway and the endoplasmic reticulum stress pathway. Anti-Cancer Drugs, 24, 73-83, 2013.

• Ribeiro, GA; Cunha-Júnior, EF; Pinheiro, RO; Silva, SAG; Canto-Cavalheiro, MM; Silva, AJM; Costa, PRR; Netto, CD; Melo, RCN; Almeida-Amaral, EE; Torres-Santos, EC. LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis. Journal of Antimicrobial Chemotherapy (Print), 68, 789-799, 2013.

• Nichols, DB; Leão, RAC; Basu, A; Chudayeu, M; Moraes, PF; Talele, TT; Costa, PRR; Kaushik-Basu, N. Evaluation of coumarin and neoflavone derivatives as HCV NS5B polymerase inhibitors. Chemical Biology & Drug Design (Print), 81, 607-614, 2013.

• Fernandes, TA; Vaz, BG; Silva, AJM; Esteves, PM; Eberlin, MN; Costa, PRR. Palladium-catalyzed arylation of enoates with iodobenzene: stereoselective synthesis of trisubstituted olefins. Journal of the Brazilian Chemical Society (Impresso), 24, 500-506, 2013.

• Reis, FRS; Faria, FCC; Souza, PS; Vasconcelos, FC; Castro, CP; Bello, RD; Silva, AJ; Costa, PRR; Maia, RC. The therapeutical potential of a novel pterocarpanquinone LQB-118 to target inhibitor of apoptosis proteins in acute myeloid leukemia cells. Anti-Cancer Agents in Medicinal Chemistry, 13, 341-351, 2013.

Roberto Takashi Sudo

• Silva, GAP; Kummerle, AE; Antunes, F; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G; Sudo, RT. Impairment of locomotor activity induced by the novel N-Acylhydrazone derivatives LASSBio-785 and LASSBio-786 in mice. Brazilian Journal of Medical and Biological Research (Impresso), 46, 263-269, 2013.

• Alencar, AKND; Pereira SL; Maia, RC; Landgraf, SS; Caruso-Neves, C; Tesch, R; Nascimento, JHM; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Beneficial effects of a novel agonist of the adenosine A2A receptor on monocrotaline-induced pulmonary hypertension in rats. British Journal of Pharmacology, 169, 953-962, 2013.

• Pereira SL; Marques A; Sudo, RT; Kaplan, MAC; Zapata-Sudo, G. Vasodilator activity of the essential oil from aerial parts of Pectis brevipedunculata and its main constituent citral in rat aorta. Molecules (Basel. Online), 18,3072-3085, 2013.

• Pereira SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Rocha NN; Ferraz F; Nascimento, JHM; Sudo, RT; Zapata-Sudo, G. A novel Ca²+ channel antagonist reverses cardiac hypertrophy and pulmonary arteriolar remodeling in experimental pulmonary hypertension. European Journal of Pharmacology, 702, 316-322, 2013.

• Mendes, TCF; Antunes, F; Trachez MM; Nascimento-Junior, NM; Fraga, CAM; Barreiro, EJ; Zapata-Sudo, G; Sudo, RT. Antihyperalgesic effects of a novel muscarinic agonist (LASSBio-873) in spinal nerve ligation in rats. Clinical and Experimental Pharmacology & Physiology, 40, 404-411, 2013.

• Alencar, AKND; Pereira SL; Cunha, VMN; Lima, LM; Tesch, R; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. A novel adenosine A2A receptor agonist attenuates the progression of monocrotaline-induced pulmonary hypertension in rats. Journal of Pulmonary & Respiratory Medicine, S4, 1-6, 2013.

Stefan Laufer

• Owona, BA; Njayou, NF; Laufer, SA; Schluesener, HJ; Moundipa, PF. Entada africana fraction CH2Cl2/MEOH 5% inhibits inducible nitric oxide synthase and proinflammatory cytokines gene expression induced by lipopolysaccharide in microglia, BMC Complementary and Alternative Medicine, 13, Article Number: 254, 2013.

• Hettler, A; Werner, S; Eick, S; Laufer, S; Weise, F. A new in vitro model to study cellular responses after thermomechanical damage in monolayer cultures. PLOS ONE, 8 12, e82635, 2013.

• Baur, B; Martz, KE; Goettert, MI; Richters, A; Rauh, D; Laufer, SA. Metabolically stable dibenzo[b,e]oxepin-11(6h)-ones as highly selective p38 MAP kinase inhibitors: optimizing anti-cytokine activity in human whole blood. Journal of Medicinal Chemistry, 56, 8561–8578, 2013.

• Ramer, R; Walther, U; Borchert, P; Laufer, SA; Linnebacher, M; Hinz, B. Induction but not inhibition of cox-2 confers human lung cancer cell apoptosis by celecoxib. Journal of Lipid Research, 54, 3116-3129, 2013.

• Kader, HMA; Nalin, N; El-Zeiry, M; Laufer, SA; Adrian, TE. Effects of a combined cyclooxygenase/lipoxygenase inhibitor in pancreatic cancer. Pancreas, 42, 1357, 2013.

• Ayissi, BO; Njayou, FN; Laufer, SA; Moundipa, PF; Schluesener, HJ. A fraction of stem bark extract of Entada Africana suppresses lipopolysaccharide-induced inflammation in RAW 264.7 cells. Journal of Ethnopharmacology, 149, 162-168, 2013.

• Borst, O; Walker, B; Münzer, P; Russo, A; Schmid, E; Faggio, C; Bigalke, B; Laufer, S; Gawaz, M; Lang , F. Skepinone-L, a novel potent and highly selective inhibitor of p38 MAP kinase, effectively impairs platelet activation and thrombus formation. Cell Physiology and Biochemistry, 31, 1-9, 2013.

• Kulkarnia, RG; Laufer, S; Mangannavar, C; Garlapati, A. Design, synthesis and characterization of n‘, n‘‘-diaryl ureas as p38 kinase inhibitors. Medicinal Chemistry, 9, 213-221, 2013.

• Naujokat, C; Laufer, S. Targeting cancer stem cells with defined compounds and drugs. Journal of Cancer Research Updates, 2, 36-67, 2013.

• Atemnkeng, VAA; Pink, M; Schmitz-Spanke, S; Wu, X; Dong, L; Zhao, K; May, C; Laufer, S; Langer, B; Kaiser, A. Deoxyhypusine hydroxylase from Plasmodium vivax, the neglected human malaria parasite: Molecular cloning, expression and specific inhibition by the 5-LOX inhibitor zileuton. PLOS ONE, 8, e58318, 2013.

• Laufer, S; Holzgrabe, U; Steinhilber, D. Drug Discovery: A modern decathlon. Angew. Chem. Int. Ed. 125, 4072 – 4076, 2013.

• Koeberle, A; Shindou, H; Koeberle, SC; Laufer, SA; Shimizu, T; Werz, O. Arachidonoyl-phosphatidylcholine oscillates during the cell cycle and counteracts proliferation by suppressing akt membrane binding. Proceedings of the National Academy of Science, 110, 2546-2551, 2013.

• Kulkarni, RG; Laufer, SA; Chandrashekhar, VM; Garlapati, A. Synthesis, p38 kinase inhibitory and anti-inflammatory activity of new substituted benzimidazole derivatives. Medicinal Chemistry, 9, 91-99, 2013.

• Fischer, S; Wentsch, HK; Mayer-Wrangowski, SC; Zimmermann, M; Bauer, SM; Storch, K; Niess, R; Koeberle, SC; Grütter, C; Boeckler, FM; Rauh, D; Laufer, SA. Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low atp competitiveness and outstanding whole blood activity. Journal of Medicinal Chemistry, 56, 2013.

Valéria do Monti Nascimento Cunha

• Rodriguez, JBR; Muzi-Filho, H; Valverde, RH; Quintas, LEM; Noël, F; Einicker, M; Cunha, VMN. Rat vas deferens SERCA2 is modulated by Ca2+/calmodulin protein kinase II-mediated phosphorylation. Brazilian Journal of Medical and Biological Research on line, 46, 227-234, 2013.

• Muzi-Filho, H; Bezerra, CGP; Souza, AM; Boldrini, LC; Takiya, CM; Oliveira, FL; Nesi, RT; Valença, SS; Einicker-Lamas, M; Vieyra, A; Lara, LS; Cunha, VMN. Undernutrition affects cell survival, oxidative stress, Ca2+ handling and signaling pathways in vas deferens, crippling reproductive capacity. Plos One, 8, e69682, 2013.

• Rezende, DC; Pôças, ESC; Muzi-Filho, H; Cunha, VMN; Caricati-Neto, A; Jurkiewicz, A; Noël, F; Quintas, LEM. Mechanisms associated to impaired activity of cardiac P-type ATPases in endothelial nitric oxide synthase knockout mice. Journal of Physiology and Biochemistry, 69, 207-214, 2013.

• Alencar, AKN; Pereira, SL; Silva, FE; Cunha, VMN; Lima, LM; Tesch, R; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; G. A novel adenosine A2a receptor agonist atenuates the progression of monocrotaline-induced pulmonary hypertension in rats. Journal of Pulmonary & Respiratory Medicine, 1, 1-6, 2013.

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