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Ana Luisa Palhares de Miranda

• Lacerda, RB; Sales, NM; Silva, LL; Tesch, R; Miranda, ALP; Barreiro, EJ; Fernandes, PD; Fraga, CAM. Novel potent imidazo[1,2-a]pyridine-n-glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies. Plos One, 9, e91660, 2014.

• Lima, CKF; Silva, RM; Lacerda RB; Santos, BLR; Silva, RV; Amaral, LS; Quintas, LEM; Fraga, CAM; Barreiro, EJ; Guimaraes, MZP; Miranda, ALP . LASSBio-1135: A dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. Plos One, 9, e99510, 2014.

Carlos Alberto Manssour Fraga

• Pereira, SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca2+ channels. Fundamental & Clinical Pharmacology, 28, 29-41, 2014.

• Silva, JS; Pereira, SL; Maia, RC; Landgraf, SS; Caruso-Neves, C; Kümmerle, AE;Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-Acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life Sciences (1973), 94, 30-36, 2014.

• Lacerda, RB; Sales, NM; Silva, LL; Tesch, R; Miranda, ALP; Barreiro, EJ; Fernandes, PD; Fraga, CAM. Novel potent imidazo[1,2-a]pyridine-n-glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies. Plos One, 9, e91660, 2014.

• Alencar, AKN; Pereira, SL; Silva, FE; Mendes, LVP; Cunha, VMN; Lima, LM; Montagnoli, TL; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertensionthrough the modulation of adenosine AA2R activity. International Journal of Cardiology (Print), 173, 154-162, 2014.

• Alencar, AKN; Pereira, SL; Silva, FE; Cunha, VMN; Lima, LM; Tesch, R; Santanna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. A novel adenosine A2a receptor agonist attenuates the progression of monocrotaline-induced pulmonary hypertension in rats. Journal of Pulmonary & Respiratory Medicine, S4, 005, 2014.

• Lima, CKF; Silva, RM; Lacerda, RB; Santos, BLR; Silva, RV; Amaral, LS; Quintas, LEM; Fraga, CAM;Barreiro, EJ; Guimaraes, MZP; Miranda, ALP. LASSBio-1135: A dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. Plos One, 9, e99510, 2014.

• Silva, RBs; Silva, EF; Carvalho, SA; Fraga, CAM; Wardell, SMSV; Wardell, JL. Crystal structures of 1-hydroxylimidazole and imidazole 1-oxide derivatives. Zeitschrift für Kristallographie, 229, 709-722, 2014.

• Maia, RC; Tesch, R; Fraga, CAM. Acylhydrazone derivatives: a patent review. Expert Opinion on Therapeutic Patents, 24, 1161-1170, 2014.

• Carvalho, S; Kaiser, M; Brun, R; Silva, E; Fraga, CAM. Antiprotozoal activity of (E)-cinnamic n-acylhydrazone derivatives. Molecules (Basel. Online), 19, 20374-20381, 2014.

Cláudia Lucia Martins da Silva

• Chagas-Silva, F; Nascimento-Viana, JB; Romeiro, LAS; Barberato, LC; Noël, F; Silva, CLM. Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth. Naunyn-Schmiedeberg's Archives of Pharmacology, 387, 225-234, 2014.

• Oliveira, SDS; Nanini, HF; Baggio, LES; Waghabi, MC; Silva, CLM; Coutinho-Silva, R. Macrophage P2X7 receptor function is reduced during schistosomiasis: putative role of TGF- 1. Mediators of Inflammation, 2014, 1-12, 2014.

Didier Jean Jacques Salmon

• Ribeiro, JMCG, Sorgine, FA; Logullo, MHF; Mesquita, R; Silva, RDP; Majerowicz, GO; Medeiros, D; Koerich, D; Terra, L; Ferreira, WR; Pimentel, C; Bisch, AC; Leite, PM; Diniz, DC; Junior, MMP. An insight into the transcriptome of the digestive tract of the bloodsucking bug, Rhodnius prolixus. PLoS Neglected Tropical Diseases (Online), 8, e2594, 2014.

Eliezer Jesus de Lacerda Barreiro

• Barbosa, MLC; Lima, LM; Tesch, R; Sant'anna, CMR; Totzke, F; Kubbutat, MHG; Schächtele, C; Laufer, SA; Barreiro, EJ. Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors. European Journal of Medicinal Chemistry, 71, 1-14, 2014.

• Silva, JS; Pereira, SL; Maia, RC; Landgraf, SS; Caruso-Neves, C; Kümmerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life Sciences (1973), 94, 30-36, 2014.

• Lima, CKF; Silva, RM; Lacerda, RB; Santos, BLR; Silva, RV; Amaral, LS; Quintas, LEM; Fraga, CAM; Barreiro, EJ; Guimaraes, MZP; Miranda, ALP. LASSBio-1135: A dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. Plos One, 9, e99510, 2014.

• Nunes, IC; Tinoco, LW; Martins-Junior, H; Rezende, C; Barreiro, EJ; Lima, LM. In vitro microsomal hepatic metabolism of antiasthmatic prototype LASSBio-448. Current Topics in Medicinal Chemistry (Print), 14, 1388-1398, 2014.

• Barreiro, EJ; Carvalho, GMC; Gomes, MDM; Oliveira, VR; Casquilho, NV; Araujo, AP; Soares, RM; Azevedo, SO; Monteiro, APT; Canetti, C; Lima, LM; Zin, WA. Pulmonary and hepatic injuries caused by the subchronic exposure to microcystin-lr: role of the duration of treatment with LASSBio-596. Seminars in Respiratory and Critical Care Medicine, 189, A5023-A5023, 2014.

• Lacerda, RB; Sales, NM; Silva, LL; Tesch, R; Miranda, ALP; Barreiro, EJ; Fernandes, PD; Fraga, CAM. Novel potent imidazo[1,2-a]pyridine-n-glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies. Plos One, 9, e91660, 2014.

• Amaral, DN; Cavalcanti, BC; Bezerra, DP; Ferreira, PMP; Castro, RP; Sabino, JR; Machado, CML; Chammas, R; Pessoa, C; Sant'anna, CMR; Barreiro, EJ; Lima, LM. Docking, synthesis and antiproliferative activity of n-acylhydrazone derivatives designed as combretastatin a4 analogues. Plos One, 9, e85380, 2014.

• Pereira, SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Vasodilator and antihypertensive effects of a novel N -acylhydrazone derivative mediated by the inhibition of L-type Ca2+ channels. Fundamental & Clinical Pharmacology, 28, 29-41, 2014.

• Sampaio, TS; Lima, LM; Zardo, RS; Cavalcanti, BC; Castro, RP; Sabino, JR; Fernandes, PD; Barreiro, EJ. Synthesis, antiproliferative and anti-inflammatory activities of novel simplified imatinib analogues. Medicinal Chemistry, 4, 756-762, 2014.

• Lima, LM; Trachez, MM; Araujo, JSC; Silva, JS; Amaral, DN; Barreiro, EJ; Zapata-Sudo, G. Novel partial agonist of PPAR-gamma for treatment of diabetic neuropathy in rats. Journal of Diabetes & Metabolism, 05, 392-396, 2014.

• Araujo, GL; Vieira, AED; Barreiro, EJ; Lima, LM; Cardoso, CN; Emiliano, NF; Martins, MT; Souza, SS; de Souza, AM; Berto, C; Costa, ML; Campos, LM; França, FD; Tagliati, CA. Toxicological in vitro and subchronic evaluation of LASSBio-596. Food and Chemical Toxicology, 73, 148-156, 2014.

• Sato, JAP; Costa, FN; Rocha, MD; Barreiro, EJ; Fraga, CAM; Punzo, F; Ferreira, FF. Structural characterization of LASSBio-1289: a new vasoactive N-methyl-N-acylhydrazone derivative. CrystEngComm (Cambridge. Online), 17, 165-173, 2014.

• Alencar, AKN; Pereira, SL; Silva, FE; Mendes, LVP; Cunha, VMN; Lima, LM; Montagnoli, TL; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Sant'anna, CMR; Fraga, AM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity. International Journal of Cardiology (Print), 173, 154-162, 2014.

Fabio de Sousa Menezes Boylan

• Pinheiro, MMG; Radulovic, NS; Miltojevic, AB; Boylan, F; Fernandes, PD. Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain. European Journal of Pharmacology, 727, 106-114, 2014.

Floriano Paes Silva Junior

• Romao-Dumaresq, AS; Froes, AM; Cuadrat, RRC; Silva, FP; Davila, AMR. Towards a comprehensive search of putative chitinases sequences in environmental metagenomic databases. Natural Science (Print), 06, 323-337, 2014.

• Menna-Barreto, RFS; Belloze, KT; Perales, J; Silva-Jr, FP. Proteomic and Bioinformatic analysis of Trypanosoma cruzi chemotherapy and potential drug targets: new pieces for an old puzzle. Current Drug Targets (Print), 15, 255-271, 2014.

• Tschoeke, DA; Nunes, GL; Jardim, R; Lima, J; Romao-Dumaresq, AS; Gomes, MR; Pereira, LM; Loureiro, D; Stoco, PH; Silva-jr, FP; Davila, AMR. The Comparative Genomics and Phylogenomics of Leishmania amazonensis Parasite. Evolutionary Bioinformatics Online, 10, 131-153, 2014.

• Forezi, LSM; Tolentino, NMC; Souza, AMT; Castro, HC; Montenegro, RC; Dantas, RF; Oliveira, MEIM; Silva-Jr, Floriano Paes; Ferreira, VF; Cunha, AC; Boechat, FCS; Souza, M. CBV. Synthesis, cytotoxicity and mechanistic evaluation of 4-oxoquinoline-3-carboxamide derivatives: finding new potential anticancer drugs. Molecules (Basel. Online), 19, 6651-6670, 2014.

• Cardoso, MFC; Rodrigues, PC; Oliveira, MEIM; Gama, IL; Silva, IMCB; Santos, IO; Rocha, DR; Pinho, RT; Ferreira, VF; Souza, MCBV; Silva, FC; Silva Junior, FP. Synthesis and evaluation of the cytotoxic activity of 1,2-furanonaphthoquinones tethered to 1,2,3-1H-triazoles in myeloid and lymphoid leukemia cell lines. European Journal of Medicinal Chemistry, 84, 708-717, 2014.

• Gonzaga, D; Senger, MR; Silva, FC; Ferreira, VF; Silva, FP. 1-Phenyl-1H- and 2-phenyl-2H-1,2,3-triazol derivatives: Design, synthesis and inhibitory effect on alpha-glycosidases. European Journal of Medicinal Chemistry, 74, 461-476, 2014.

François Germain Noel

• Silva, FC; Barbosa, JN; Romeiro, LAS; Barberato, LC; Noël, F; Silva, CLM. Pharmacological characterization of N1-(2-methoxyphenyl)-N4-hexylpiperazine as a multi-target antagonist of α1A/α1D-adrenoceptors and 5-HT1A receptors that blocks prostate contraction and cell growth. Naunyn-Schmiedeberg's Archives of Pharmacology, 387, 225-234, 2014.

• Noel, F; Moura, BC; Pompeu, TET. Functional binding assays for estimation of the intrinsic efficacy of ligands at the 5-HT1A receptor: Application for screening drug candidates. Journal of Pharmacological and Toxicological Methods, 70, 12-18, 2014.

• Stolz, ED; Muller, LG; Antonio, CB; Costa, PF; Poser, GLV; Noël, F; Rates, SMK. Determination of pharmacological interactions of uliginosin B, a natural phloroglucinol derivative, with amitriptyline, clonidine and morphine by isobolographic analysis. Phytomedicine (Stuttgart), 21, 1684-1688, 2014.

• Rocha, SC; Pessoa, MT; Neves, LD; Alves, SL; Silva, CLM; Santos, HL; Oliveira, SM; Taranto, AG; Comar, M; Gomes, IV; Santos, FV; Paixao, N; Quintas, LE; Noël, F; Pereira, AF; Tessis, AC; Gomes, NL; Moreira, OC; Rincon-Heredia, R; Varotti, FP; Blanco, G; Villar, JA; Contreras, RG; Barbosa, LA. 21-Benzylidene Digoxin: A proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions. Plos One, 9, e108776, 2014.

• Cavalcante-Silva, LHA; Falcao, MAP; Vieira, ACS; Viana, MDM; Araujo-Junior, JX; Souza, JCF; Barbosa-Filho, JM; Miranda, GEC; Noël, F; Santos, BVO; Alexandre-Moreira, MS. Assessment of mechanisms involved in antinociception produced by the alkaloid caulerpine. Molecules (Basel. Online), 1914699-14709, 2014.

Gisele Zapata Sudo

• Silva, JS; Pereira, SL; Maia, RC; Landgraf, SS; Caruso-Neves, C; Kümmerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life Sciences (1973), 94, 30-36, 2014.

• Pereira, SL; Kummerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Vasodilator and antihypertensive effects of a novel N -acylhydrazone derivative mediated by the inhibition of L-type Ca²⁺ channels. Fundamental & Clinical Pharmacology, 28, 29-41, 2014.

• Alencar, AKN; Pereira, SL; Silva, FE; Mendes, LVP; Cunha, VMN; Lima, LM; Montagnoli, TL; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Sant’Anna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertensionthrough the modulation of adenosine A2R activity. International Journal of Cardiology (Print), 173, 154-162, 2014.

• Lima, LM; M, TM; Araujo, JSC; Silva JS; Amaral, DN; Sudo, RT; Zapata-Sudo, G. Novel partial agonist of PPAR-gamma for treatment of diabetic neuropathy in rats. Journal of Diabetes & Metabolism, 5, 392, 2014.

• Zapata-Sudo, G; Silva, JS; Pereira, SL; Souza, PJC; Moura, RS; Sudo, RT. Oral treatment with Euterpe oleracea Mart. (açaí) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. BMC Complementary and Alternative Medicine (Online), 14, 227, 2014.

• Debom, R; Trachez, MM; Zapata-Sudo, G; Silva JS; Oliveira, KM; Garcia, AL; Godoy, LM; Pacheco, PC; Sudo, RT. Novel nicotinic receptor agonist reduces hyperalgesia and allodynia of neuropathic pain in diabetic rats. Journal of Diabetes & Metabolism, 5, 396, 2014.

• Zapata-Sudo, G; Alencar, AKN; Sudo, SZ; Sudo, RT. Targeting of the adenosine receptors as a novel strategy for the treatment of arterial hypertension. Journal of Neurology and Neurophysiology, 5, 243, 2014.

• Alencar, AKN; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Adenosine A2A receptor as a target of treatment for pulmonary arterial hypertensioN. Clinical Research in Pulmonology, 2, 1021, 2014.

Josiane Sabbadini Neves

• Fernandes, PD; Guerra, FS; Sales, NM; Sardella, T; Jancar, S; Neves, JS. Characterization of the inflammatory response during Ehrlich ascitic tumor development. Journal of Pharmacological and Toxicological Methods, x, xx, 2014.

Lidia Moreira Lima

• Barbosa, MLC; Lima, LM; Tesch, R; Sant'anna, CMR; Totzke, F; Kubbutat, MHG; Schächtele, C; Laufer, SA; Barreiro, EJ. Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors. European Journal of Medicinal Chemistry, 71, 1-14, 2014.

• Costa, FN; Braz, D; Ferreira, FF; Silva, TF; Barreiro, EJ; Lima, LM; Colaço, MV; Kuplich, L; Barroso, RC. Synchrotron X-ray powder diffraction data of LASSBio-1515: A new N-acylhydrazone derivative compound. Radiation Physics and Chemistry (1993), 95, 292-295, 2014.

• Amaral, DN; Cavalcanti, BC; Bezerra, DP; Ferreira, PMP; Castro, RP; Sabino, JR; Machado, CML; Chammas, R; Pessoa, C; Sant'anna, CMR; Barreiro, EJ; Lima, LM. Docking, synthesis and antiproliferative activity of n-acylhydrazone derivatives designed as combretastatin a4 analogues. Plos One, 9, e85380, 2014.

• Alencar, AKN; Pereira, SL; Silva, FE; Mendes, LVP; Cunha, VMN; Lima, LM; Montagnoli, TL; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Sant'anna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertensionthrough the modulation of adenosine AA2R activity. International Journal of Cardiology (Print), 173, 1-9, 2014.

• Silva, Y; Reyes, C; Rivera, G; Alves, M; Barreiro, EJ; Moreira, M; Lima, LM. 3-aminothiophene-2-acylhydrazones: non-toxic, analgesic and anti-inflammatory lead-candidates. Molecules (Basel. Online), 19, 8456-8471, 2014.

• Nunes, IC; Tinoco, LW; Martins-Junior, H; Rezende, C; Barreiro, EJ; Lima, LM. In vitro microsomal hepatic metabolism of antiasthmatic prototype LASSBio-448. Current Topics in Medicinal Chemistry (Print), 14, 1388-1398, 2014.

• Lima, LM. Novel partial agonist of PPAR-gamma for treatment of diabetic neuropathy in rats. Journal of Diabetes & Metabolism, 05, 392-396, 2014.

• Araujo, GL; Vieira, AED; Barreiro, EJ; Lima, LM; Cardoso, CN; Emiliano, NF; Martins, MT; Souza, SS; Souza, AM; Berto, C; Costa, ML; Campos, LM; França, FD; Tagliati, CA. Toxicological in vitro and subchronic evaluation of LASSBio-596. Food and Chemical Toxicology, 73, 148-156, 2014.

• Lima, LM. Synthesis, antiproliferative and anti-inflammatory activities of novel simplified imatinib analogues. Medicinal Chemistry, 4, 756-762, 2014.

Lucienne da Silva Lara Morcillo

• Dias, J; Ferrão, FM; Axelband, F; Carmona, AK; Lara, LS; Vieyra, A. ANG-(3-4) inhibits renal Na+-ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors heterodimers and PKA. American Journal of Physiology. Renal Physiology, 306, F855-F863, 2014.

• Silva, PA; Monnerat-Cahli, G; Pereira-Acácio, A; Luzardo, R; Sampaio, LS; Luna-Leite, MA; Lara, LS; Einicker-Lamas, M; Panizzutti, R; Madeira, C; Vieira-Filho, LD; Castro-Chaves, C; Ribeiro, VS; Paixão, ADO; Medei, E; A . Mechanisms involving Ang II and MAPK/ERK1/2 signaling pathways underlie cardiac and renal alterations during chronic undernutrition. Plos One, 9, e100410, 2014.

• Silva, PA; Muzi-Filho, H; Pereira-Acácio, A; Dias, J; Martins, JFS; Landim-Vieira, M; Verdoorn, KS; Lara, LS; Vieira-Filho, LD; Cabral, EV; Paixão, ADO; Vieyra, A. Altered signaling pathways linked to Angiotensin II underpin the upregulation of renal Na+-ATPase in chronically undernourished rats. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1842, 1-10, 2014.

• Ferrão, Fernanda M; Lara LS; Lowe J. Renin-angiotensin system in the kidney: What is new? World Journal of Nephrology, 6, 64-76, 2014.

Luis Eduardo Menezes Quintas

• Lima, CK; Silva RM; Lacerda, R; Roedel B; Silva RV; Amaral, Luciana S; Quintas, LEM; Fraga, CAM; Barreiro, EJ; Guimarães, MZ; Miranda, ALP. LASSBio-1135: A dual TRPV1 antagonist and anti-TNF-Alpha compound orally effective in models of inflammatory and neuropathic pain. Plos One, 9, e99510, 2014.

• Rocha, SC; Pessoa, MTC; Neves, LDR; Alves, SLG; Silva, LM; Santos, HL; Varotti, F; Oliveira, SM; Taranto, A; Comar, M; Gomes, IV; Santos, FV; Paixão, N; Quintas, LEM; Noël, F; Pereira, A; Tessis, A; Gomes, N; Moreira, O; Rincon-Heredia, R; Blanco, G; Villar, J; Contreras, R; Barbosa, LA. 21-benzylidene digoxin: a proapoptotic cardenolide of cancer cells that up-regulates Na,K-ATPase and epithelial tight junctions. Plos One, 9, e108776, 2014.

Luzineide Wanderley Tinoco

• Casanova, LM; Silva, D; Sola-Penna, M; Camargo, LMM; Celestrini, DM; Tinoco, LW; Costa, SS. Identification of chicoric acid as a hypoglycemic agent from Ocimum gratissimum leaf extract in a biomonitoring in vivo study. Fitoterapia (Milano, 1934) (Cessou em 1960. Foi fundido com ISSN 1971-5498 Fitoterapia. Edizione Farmaceutica; ISSN 1971-5501 Fitoterapia. Edizione Me, 93, 132-141, 2014.

• Tinoco, LW; Fraga, Jully L; Anobom, CD; Zolessi, FR; Obal, G; Toledo, A; Pritsch, O; Arruti, C. Structural characterization of a neuroblast-specific phosphorylated region of MARCKS. Biochimica et Biophysica Acta. Proteins and Proteomics, 1844, 837-849, 2014.

• Silva, CCC; Silva, AP; Tinoco, LW; Freitas, IC; Goncalvez, J; Tapanes, NO; Souza, MMM; Aranda, DAG. Production of saturated esters from hydrolysis and hydrogenation simultaneous process. International Review of Chemical Engineering - Rapid Communications (IRECHE), 6, 9-14, 2014.

• SParente, JP; Adão, CR; Silva, BP; Tinoco, LW. Structural characterization of an acetylated glucomannan with antiinflammatory activity and gastroprotective property from Cyrtopodium andersonii. Carbohydrate Research (Chicago, Ill.. Print), 391, 16-21, 2014.

• Nunes, IKC; Tinoco, LW; Martins-Junior, H; Rezende, C; Barreiro, EJ; Lima, LM. In vitro microsomal hepatic metabolism of antiasthmatic prototype LASSBio-448. Current Topics in Medicinal Chemistry (Print), 14, 1388-1398, 2014.

• Ferreira, C; Soares, DC; Nascimento, MTCD; Pinto-da-Silva, LH; Sarzedas, CG; Tinoco, LW; Saraiva, EM. Resveratrol is active against leishmania amazonensis: in vitro effect of its association with amphotericin B. Antimicrobial Agents and Chemotherapy (Print), 58, 6197-6208, 2014.

Marco Aurélio Martins

• Ribeiro-Filho, J; Leite, FC; Costa, HF; Calheiros, AS; Torres, RC; Azevedo, CT; Martins, MA; Dias, CS; Bozza, PT; Piuvezam, MR. Curine inhibits mast cell-dependent responses in mice. Journal of Ethnopharmacology, 155, 1118-1124, 2014.

Marília Zaluar Passos Guimarães

• Lima, CKF; Silva, RM; Lacerda, RB; Santos, BLR; Silva, RV; Amaral, LS; Quintas, LEM; Fraga, CAM; Barreiro, EJ; Guimaraes, MZP; Miranda, ALP. LASSBio-1135: A dual TRPV1 antagonist and anti-TNF-alpha compound orally effective in models of inflammatory and neuropathic pain. Plos One, 9, e99510, 2014.

Newton Gonçalves de Castro

• Diniz, LP; Tortelli, V; Garcia, MN; Araújo, APB; Melo, HM; Silva, Gisele SS; Felice, FG; Alves-Leon, SV; Souza, JM; Romão, LF; Castro, NG; Gomes, FCA . Astrocyte transforming growth factor beta 1 promotes inhibitory synapse formation via CaM kinase II signaling. GLIA (New York, N.Y. Print), 62, 1917-1931, 2014.

Nubia Boechat

• Ferrreira, VF; Rocha, D; Silva, F; Ferreira, P; Boechat, N; Magalhães JL. Novel 1 -1,2,3-, 2 -1,2,3-, 1 -1,2,4- and 4 -1,2,4-triazole derivatives: a patent review (2008 2011). Expert Opinion on Therapeutic Patents, 23, 319-331, 2013.

• Honorato, SB; Mendonca, JS; Boechat, N; Oliveira, AC; Mendes-Filho, J; Ayala, AP. Novel polymorphs of the anti-Trypanosoma cruzi drug benznidazole. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy (Print), 118, 389-394, 2014.

• Ferreira, MLG; Pinheiro, LCS; Santos-Filho, OA; Peçanha, MDS; Sacramento, CQ; Machado, V; Ferreira, VF; Souza, TML; Boechat, N. Design, synthesis, and antiviral activity of new 1H-1,2,3-triazole nucleoside ribavirin analogs. Medicinal Chemistry Research, 23, 1501-1511, 2014.

• Boechat, N; Ferreira, MLG; Pinheiro, LCS; Aguiar, AC; Andrade, IM; Krettli, AU. New compounds hybrids 1 -1,2,3-triazole-quinoline against. Chemical Biology & Drug Design (Print), 84, 325-332, 2014.

• França, RRF; Carvalho, AS; Branco, FSC; Pinto, AC; Boechat, N. Potent inhibitors of the enzyme sterol 14α-demethylase against. Revista Virtual de Química, 6, 1483-1516, 2014.

• Boechat, N; Pinheiro, LCS; Pinto, AC; Silva, TS; Wardell, JL; Wardell, SMSV. Crystal structures of two anhydrous and one hydrated 7-(arylamino)-5-methyl-2-(trifluoromethyl)-[1,2,4]-triazolo-[1,5-a]pyrimidine derivatives. Zeitschrift für Kristallographie, 229, 459-471, 2014.

• Carvalho, AS; Salomão, K; Castro, SL; Conde, TR; Zamith, HPS; Caffarena, ER; Hall, BS; Wilkinson, SR; Boechat, N. Megazol and its bioisostere 4H-1,2,4-triazole: comparing the trypanocidal, cytotoxic and genotoxic activities and their in vitro and in silico interactions with the Trypanosoma brucei nitroreductase enzyme. Memórias do Instituto Oswaldo Cruz (Impresso), 1-9, 315-323, 2014.

Patricia Dias Fernandes

• Lacerda, RB; Sales, NM; Silva, LL; Tesch, R; Miranda, ALP; Barreiro, EJ; Fernandes, PD; Fraga, CAM. Novel potent imidazo[1,2-a]pyridine-n-glycinyl-hydrazone inhibitors of TNF-α production: in vitro and in vivo studies. Plos One, 9, e91660, 2014.

• Pinheiro, MMG; Radulovic, NS; Miltojevic, AB; Boylan, F; Fernandes, PD. Antinociceptive esters of N-methylanthranilic acid: Mechanism of action in heat-mediated pain. European Journal of Pharmacology, 727, 106-114, 2014.

• Fernandes, PD; Guerra, FS; Sales, NM; Sardella, TB; Jancar, S; Neves, JS. Characterization of the inflammatory response during Ehrlich ascitic tumor development. Journal of Pharmacological and Toxicological Methods, 71, 83-89, 2014.

• Fernandes, PD; Zardo, RS; Figueiredo, GSM; Silva, BV; Pinto, AC. Anti-inflammatory properties of convolutamydine A and two structural analogues. Life Sciences (1973), 116, 16-24, 2014.

Paulo de Assis Melo

• Saturnino-Oliveira, J; Melo, PA; Quintans, LJ. Medicinal plants in the treatment of snakebite: a technological forecasting. Revista Geintec: gestão, inovação e tecnologias, 4, 902-909, 2014.

• Fernandes, FFA; Tomaz, MA; El-Kik, Camila Z; Monteiro-Machado, M; Strauch, MA; Cons, BL; Tavares-Henriques, MS; Cintra, ACO; Facundo, VA; Melo, PA. Counteraction of Bothrops snake venoms by Combretum leprosum root extract and arjunolic acid. Journal of Ethnopharmacology, 155, 552-562, 2014.

• Saturnino-Oliveira, J; Tomaz, MA; Monteiro-Machado, M; Melo PA; Quintans-Junior, LJ. Abarema cochliacarpos Extract Decreases the Inflammatory Process and Skeletal Muscle Injury Induced by Bothrops leucurus Venom. Biomed Res Int, 2014, 1-9, 2014.

• Adade, CM; Carvalho, ALO; Tomaz, MA; Costa, TFR; Godinho, jL; Melo, PA; Lima, APCA; Rodrigues, JCF; Zingali, RB; Souto-Padrón, T. Crovirin, a snake venom cysteine-rich secretory protein (crisp) with promising activity against trypanosomes and leishmania. PLoS Neglected Tropical Diseases (Online), 8, e3252-e3259, 2014.

Paulo Roberto Ribeiro Costa

• Fernandes, TA; Domingos, JLO; Rocha, LIA; Medeiros, S; Nájera, C; Costa, PRR. Synthesis of 5-carbapterocarpens by α-arylation of tetralones followed by one-pot demethylation/cyclization with BBr3. European Journal of Organic Chemistry (Print), 2014, 1314-1320, 2014.

• Buarque, CD; Salustiano, EJ; Fraga, KC; Alves, BRM; Costa, PRR. 11a-N-Tosyl-5-deoxi-pterocarpan (LQB-223), a promising prototype for targeting MDR leukemia cell lines. European Journal of Medicinal Chemistry, 78, 190-197, 2014.

• Moraes, GN; Castro, C; Salustiano, E; Dumas, M; Costas, F; Lam, E; Costa, PRR; Maia, R. The pterocarpanquinone LQB-118 induces apoptosis in acute myeloid leukemia cells of distinct molecular subtypes and targets FoxO3a and FoxM1 transcription factors. International Journal of Oncology, 45, 1949-1958, 2014.

• Costa, L; Pinheiro, RO; Dutra, PML; Santos, RF; Cunha-Júnior, EF; Torres-Santos, EC; Silva, AJM; Costa, PRR; Silva, SAG. Pterocarpanquinone LQB-118 induces apoptosis in Leishmania (viannia) braziliensis and controls lesions in infected hamsters. Plos One, 9, e109672, 2014.

• Cortopassi, Wilian A; Penna-Coutinho, Julia; Aguiar, Anna CC; Pimentel, André S; Buarque, Camilla D; Costa, Paulo RR; Alves, Bruna RM; França, Tanos CC; Krettli, Antoniana U. Theoretical and Experimental Studies of New Modified Isoflavonoids as Potential Inhibitors of Topoisomerase I from Plasmodium falciparum. Plos One, 9, e91191, 2014.

• Martino, T; Magalhães, FCJ; Justo, GA; Coelho, MGP; Netto, CD; Costa, PRR; Sabino, KCC. The pterocarpanquinone LQB-118 inhibits tumor cell proliferation by downregulation of c-Myc and cyclins D1 and B1 mRNA and upregulation of p21 cell cycle inhibitor expression. Bioorganic & Medicinal Chemistry (Print), 22, 3115-3122, 2014.

Roberto Takashi Sudo

• Pereira, SL; Kummerle, AE; Manssour, CAF; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Vasodilator and antihypertensive effects of a novel N-acylhydrazone derivative mediated by the inhibition of L-type Ca²⁺ Channels. Fundamental & Clinical Pharmacology, 28, 29-41, 2014.

• Silva, JS; Pereira, SL; Maia, RC; Landgraf, SS; Caruso-Neves, C; Kümmerle, AE; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone improves exercise intolerance in rats submitted to myocardial infarction by the recovery of calcium homeostasis in skeletal muscle. Life Sciences (1973), 94, 30-36, 2014.

• Alencar, AKN; Pereira, SL; Silva, FE; Mendes, LVP; Cunha, VMN; Lima, LM; Montagnoli, TL; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Sant'anna, CMR; Fraga, CM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertension through the modulation of adenosine AA2R activity. International Journal of Cardiology (Print), 173, 154-162, 2014.

• Lima, LM; Trachez MM; Araujo, JSC; Silva, JS; Amaral, DN; Sudo, RT; Barreiro, EJ; Zapata-Sudo, G. Novel partial agonist of PPAR-gamma for treatment of diabetic neuropathy in rats. Journal of Diabetes & Metabolism, 5, 392-395, 2014.

• Zapata-Sudo, G; Silva, JS; Pereira SL; Pergentino JS; Moura RS; Sudo, RT. Oral treatment with Euterpe oleracea Mart. (açai) extract improves cardiac dysfunction and exercise intolerance in rats subjected to myocardial infarction. BMC Complementary and Alternative Medicine (Online), 14, 227-232, 2014.

• Debom, R; Trachez MM; Zapata-Sudo, G; Silva, JS; Oliveira, KM; Garcia, AL; Godoy LM; Pacheco OC; Sudo, RT. Novel nicotinic receptor agonist reduces hyperalgesia and allodynia of neuropathic pain in diabetic rats. Journal of Diabetes & Metabolism, 5, 396-400, 2014.

• Alencar, AKN; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. Adenosine A2A receptor as a target of treatment for pulmonary arterial hypertension. Clinical Research in Pulmonology, 2, 1021, 2014.

• Zapata-Sudo, G; Sudo, SZ; Alencar, AKN; Sudo, RT. Targeting of the adenosine receptors as a novel strategy for the treatment of arterial hypertension. Journal of Neurology and Neurophysiology, 5, 243, 2014.

Stefan Laufer

• Basting, RT; Nishijima, CM; Lopes, JA; Santos, RC; Perico, LL; Laufer, S; Bauer, S; Costa, MF; Santos, LC; Rocha, LRM; Vilegas, W; Santos, ARS; Santos, C; Hiruma-Lima, CA; Antinociceptive, anti-inflammatory and gastroprotective effects of a hydroalcoholic extract from the leaves of Eugenia punicifolia (Kunth) DC. in rodents. Journal of Ethnopharmacology, 157, 257-267, 2014.

• El-Said, OM; Hamed, MM; Laufer, S; Abadi, AH, Design and synthesis of novel quinazoline derivatives and their evaluation as PI3Ks inhibitors. Chemical & Pharmaceutical Bulletin, 62, 12, 1166-1172, 2014.

• Rudalska, R; Dauch, D; Longerich, T; McJunkin, K; Wuestefeld, T; Kang, TW; Hohmeyer, A; Pesic, M; Leibold, J; von Thun, A; Schirmacher, P; Zuber, J; Weiss, KH; Powers, S; Malek, NP; Eilers, M; Sipos, B; Lowe, SW; Geffers, R; Laufer, S; Zender, L. In vivo RNAi screening identifies a mechanism of sorafenib resistance in liver cancer. Nature Medicine, 20, 1138-1146, 2014.

• Hosseinzadeh, Z; Schmid, E; Shumilina, E; Laufer, S; Borst, O; Gawaz, M; Lang, F. Effect of TGF beta on Na+/K+ ATPase activity in megakaryocytes. Biochemical and Biophysical Research Communications, 452, 537-541, 2014.

• Bauer, SM; Gehringer, M; Laufer, SA. A direct enzyme-linked immunosorbent assay (ELISA) for the quantitative evaluation of Janus Kinase 3 (JAK3) inhibitors. Analytical Methods, 6, 8817-8822, 2014.

• Gehringer, M; Forster, M; Pfaffenrot, E; Bauer, SM; Laufer, SA. Novel hinge-binding motifs for janus kinase 3 inhibitors: a comprehensive structure-activity relationship study on tofacitinib bioisosteres. Chemmedchem, 9, 2516-2527, 2014.

• Balfer, J; Heikamp, K; Laufer, S; Bajorath, J, Modeling of Compound Profiling Experiments Using Support Vector Machines. Chemical Biology & Drug Design, 84, 75-85, 2014.

• Ahmed, NS; Elgendy, M; Laufer, S; Abadi, AH. Discovery of a novel series of tetrahydro-beta-carbolines inducing autophagic cell death in human metastatic melanoma. Archiv Der Pharmazie, 347, 398-406, 2014.

• Geller, F; Murillo, R; Steinhauser, L; Heinzmann, B; Albert, K; Merfort, I; Laufer, S. Four new flavonol glycosides from the leaves of Brugmansia suaveolens. Molecules, 19, 6727-6736, 2014.

• Storch, K; Gehringer, M; Baur, B; Laufer, SA. Metabolism of a novel skepinone L-like p38 mitogen-activated protein kinase inhibitor. MedChemComm, 5, 808-815, 2014.

• Anton, R; Bauer, SM; Peter, RW; Keck, EF; Laufer, E; Rothbauer, U. A p38 substrate-specific MK-EGFP translocation assay for identification and validation of new p38 inhibitors in living cells: a comprising alternative for acquisition of cellular p38 inhibition data. PLOS ONE, 9, e95641, 2014.

• Bühler, S; Laufer, SA. p38 MAPK inhibitors: a patent review (2012 - 2013). Expert Opinion in Therapeutics Patents, 24, 1-20, 2014.

• Scior, T; Verhoff, M; Gutierrez-Aztatzi, I; Ammon, HPT; Laufer, S; Werz, O. Interference of boswellic acids with the ligand binding domain of the glucocorticoid receptor. Journal of Chemical Information Model, 54, 978-986, 2014.

• Balfer, J; Heikamp, K; Laufer, S; Bajorath, J. Modeling of compound profiling experiments using support vector machines. Chemical Biology & Drug Design, 84, 75-85, 2014.

• Schrott, E; Laufer, S; Lämmerhofer, M; Ammon, HPT. Extract from gum resin of Boswellia serrata decreases IA2 – antibody in a patient with Late onset autoimmune diabetes of the adult (LADA). Phytomedicine, 21, 786-786, 2014.

• Gehringer, M; Pfaffenrot, E; Bauer, S; Laufer, SA. Synthesis of picomolar tricyclic JAK3 inhibitors via intramolecular heck reaction. ChemMedChem, 9, 277–281, 2014.

• Koch, DA; Silva, RBM; Souza, AH; Leite, CE; Nicoletti, NF; Campos, MM; Laufer, S; Morrone, FB. Efficacy and gastro-intestinal tolerability of ML3403, a selective inhibitor of p38 MAP kinase and CBS-3595, a dual inhibitor of p38 MAP kinase and phosphodiesterase 4 in CFA-induced arthritis in rats. Rheumatology,53, 425-432, 2014.

• Barbosa, MLD; Lima, LM; Tesch, R; Sant'Anna, CMR; Totzke, F; Kubbutat, MHG; Schachtele, C; Laufer, SA; Barreiro, EJ: Novel 2-chloro-4-anilino-quinazoline derivatives as EGFR and VEGFR-2 dual inhibitors. European Journal of Medicinal Chemistry, 71, 1-14, 2014.

Valéria do Monti Nascimento Cunha

• Alencar, AKN; Pereira, SL; Silva, FE; Mendes, LVP; Cunha, VMN; Lima, LM; Montagnoli, TL; Caruso-Neves, C; Ferraz, EB; Tesch, R; Nascimento, JHM; Sant’Anna, CMR; Fraga, CAM; Barreiro, EJ; Sudo, RT; Zapata-Sudo, G. N-acylhydrazone derivative ameliorates monocrotaline-induced pulmonary hypertensionthrough the modulation of adenosine A2R activity. International Journal of Cardiology (Print), 173, 154-162, 2014.

• Muzi-Filho, H; Souza, DRA; Scaramello, CBV; Cunha, VMN. Ivermectin inhibits both the plasma membrane and the sarcoplasmic/endoplasmic reticulum Ca2⁺-ATPases (PMCA and SERCA) in the rat vas deferens. Revista de Ciências Médicas, 23, 75-82, 2014.

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